| Gene Symbol |
NAA10
|
| Entrez Gene |
8260
|
| Alt Symbol |
ARD1, ARD1A, ARD1P, DXS707, MCOPS1, NATD, TE2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
N(alpha)-acetyltransferase 10, NatA catalytic subunit
|
| Other Description |
ARD1 homolog A, N-acetyltransferase|N-acetyltransferase ARD1, human homolog of|N-alpha-acetyltransferase 10|N-alpha-acetyltransferase 10, NatA catalytic subunit|N-terminal acetyltransferase complex ARD1 subunit homolog A|natA catalytic subunit Naa10
|
| Swissprots |
P41227 A6NM98
|
| Accessions |
EAW72773 EAW72774 EAW72775 EAW72776 P41227 AK294081 BAG57422 AK296593 BAG59209 AK309083 AK315997 BAH14368 AM392552 CAL37430 AM393827 CAL38702 AY183134 AY183135 BC000308 AAH00308 BC019312 AAH19312 BC063377 AAH63377 BI192945 CA313208 CR979270 X77588 CAA54691 NM_001256119 NP_001243048 NM_001256120 NP_001243049 NM_003491 NP_003482
|
| Function |
Catalytic subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. The NAT activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation. Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration. Acetylates, and stabilizes TSC2, thereby repressing mTOR activity and suppressing cancer development. {ECO:0000269|PubMed:12464182, ECO:0000269|PubMed:15496142, ECO:0000269|PubMed:19826488, ECO:0000269|PubMed:20145209}.
|
| Subcellular Location |
Cytoplasm. Nucleus. Note=According to PubMed:12464182 it is cytoplasmic. According to PubMed:15496142, it is nuclear and cytoplasmic. Also present in the free cytosolic and cytoskeleton-bound polysomes.
|
| Tissue Specificity |
Ubiquitous. {ECO:0000269|PubMed:12464182}.
|