| Gene Symbol |
WNT2B
|
| Entrez Gene |
7482
|
| Alt Symbol |
WNT13
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
wingless-type MMTV integration site family, member 2B
|
| Other Description |
XWNT2, Xenopus, homolog of|protein Wnt-2b|wingless-type MMTV integration site family, member 13
|
| Swissprots |
Q93097 Q9HDC2 Q5TEH9 Q9HDC1 Q5TEI2 O14903
|
| Accessions |
CAI38641 EAW56519 Q93097 AB045116 BAB11984 AB045117 BAB11985 AF028701 AAC39552 AK127449 AK307185 AK312696 BAG35575 BC141825 AAI41826 NM_001291880 NP_001278809 NM_004185 NP_004176 NM_024494 NP_078613
|
| Function |
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. May be involved in normal development or differentiation as well as in carcinogenesis.
|
| Subcellular Location |
Secreted, extracellular space, extracellular matrix.
|
| Tissue Specificity |
Isoform 1 is expressed in adult heart, brain, placenta, lung, prostate, testis, ovary, small intestine and colon. In the adult brain, it is mainly found in the caudate nucleus, subthalamic nucleus and thalamus. Also detected in fetal brain, lung and kidney. Isoform 2 is expressed in fetal brain, fetal lung, fetal kidney, caudate nucleus, testis and cancer cell lines.
|
| Top Pathways |
Proteoglycans in cancer, Wnt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Hippo signaling pathway, HTLV-I infection
|