Gene Symbol | WNT2B |
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Entrez Gene | 7482 |
Alt Symbol | WNT13 |
Species | Human |
Gene Type | protein-coding |
Description | wingless-type MMTV integration site family, member 2B |
Other Description | XWNT2, Xenopus, homolog of|protein Wnt-2b|wingless-type MMTV integration site family, member 13 |
Swissprots | Q93097 Q9HDC2 Q5TEH9 Q9HDC1 Q5TEI2 O14903 |
Accessions | CAI38641 EAW56519 Q93097 AB045116 BAB11984 AB045117 BAB11985 AF028701 AAC39552 AK127449 AK307185 AK312696 BAG35575 BC141825 AAI41826 NM_001291880 NP_001278809 NM_004185 NP_004176 NM_024494 NP_078613 |
Function | Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. May be involved in normal development or differentiation as well as in carcinogenesis. |
Subcellular Location | Secreted, extracellular space, extracellular matrix. |
Tissue Specificity | Isoform 1 is expressed in adult heart, brain, placenta, lung, prostate, testis, ovary, small intestine and colon. In the adult brain, it is mainly found in the caudate nucleus, subthalamic nucleus and thalamus. Also detected in fetal brain, lung and kidney. Isoform 2 is expressed in fetal brain, fetal lung, fetal kidney, caudate nucleus, testis and cancer cell lines. |
Top Pathways | Proteoglycans in cancer, Wnt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Hippo signaling pathway, HTLV-I infection |
Wnt-2b CRISPR/Cas9 KO Plasmid (h) - sc-405478 from Santa Cruz Biotechnology
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Wnt-2b HDR Plasmid (h) - sc-405478-HDR from Santa Cruz Biotechnology
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Wnt-2b Double Nickase Plasmid (h) - sc-405478-NIC from Santa Cruz Biotechnology
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Wnt-2b Double Nickase Plasmid (h2) - sc-405478-NIC-2 from Santa Cruz Biotechnology
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Wnt-2b CRISPR Activation Plasmid (h) - sc-405478-ACT from Santa Cruz Biotechnology
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Wnt-2b CRISPR Activation Plasmid (h2) - sc-405478-ACT-2 from Santa Cruz Biotechnology
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Wnt-2b Lentiviral Activation Particles (h) - sc-405478-LAC from Santa Cruz Biotechnology
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Wnt-2b Lentiviral Activation Particles (h2) - sc-405478-LAC-2 from Santa Cruz Biotechnology
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Wnt-2b siRNA (h) - sc-78902 from Santa Cruz Biotechnology
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Wnt-2b shRNA Plasmid (h) - sc-78902-SH from Santa Cruz Biotechnology
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Wnt-2b shRNA (h) Lentiviral Particles - sc-78902-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU091091 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22917 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22917 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06824 from Sigma-Aldrich
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WNT2B siRNA (Human) - CRH5121 from Cohesion Biosciences
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WNT2B - MBS8215299 from MyBioSource
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shRNA set against Human WNT2B (NM_004185.3) - SHH447268 from Creative biogene
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Human WNT2B siRNA - orb265623 from Biorbyt
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WNT2B shRNA Plasmid (Human) - CHH5121 from Cohesion Biosciences
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WNT2B miRNA 3'UTR clone - MiUTR4H-TG09896 from Creative biogene
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