| Gene Symbol |
ITPA
|
| Entrez Gene |
613653
|
| Alt Symbol |
-
|
| Species |
Bovine
|
| Gene Type |
protein-coding
|
| Description |
inosine triphosphatase (nucleoside triphosphate pyrophosphatase)
|
| Other Description |
ITPase|NTPase|inosine triphosphatase A|inosine triphosphate pyrophosphatase|non-canonical purine NTP pyrophosphatase|non-standard purine NTP pyrophosphatase|nucleoside triphosphate pyrophosphatase|nucleoside-triphosphate diphosphatase|nucleoside-triphosphate pyrophosphatase
|
| Swissprots |
Q2KIC5
|
| Accessions |
DAA23297 Q2KIC5 BC112688 AAI12689 NM_001076282 NP_001069750
|
| Function |
Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. {ECO:0000255|HAMAP-Rule:MF_03148}.
|
| Subcellular Location |
Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03148}.
|
| Top Pathways |
Purine metabolism, Drug metabolism - other enzymes, Pyrimidine metabolism
|