| Gene Symbol | ITPA |
|---|---|
| Entrez Gene | 613653 |
| Alt Symbol | - |
| Species | Bovine |
| Gene Type | protein-coding |
| Description | inosine triphosphatase (nucleoside triphosphate pyrophosphatase) |
| Other Description | ITPase|NTPase|inosine triphosphatase A|inosine triphosphate pyrophosphatase|non-canonical purine NTP pyrophosphatase|non-standard purine NTP pyrophosphatase|nucleoside triphosphate pyrophosphatase|nucleoside-triphosphate diphosphatase|nucleoside-triphosphate pyrophosphatase |
| Swissprots | Q2KIC5 |
| Accessions | DAA23297 Q2KIC5 BC112688 AAI12689 NM_001076282 NP_001069750 |
| Function | Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. {ECO:0000255|HAMAP-Rule:MF_03148}. |
| Subcellular Location | Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03148}. |
| Top Pathways | Purine metabolism, Drug metabolism - other enzymes, Pyrimidine metabolism |
Recombinant Bovine Inosine triphosphate pyrophosphatase(ITPA) - CSB-YP642526BO CSB-EP642526BO CSB-BP642526BO CSB-MP642526BO from Cusabio
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Inosine triphosphate pyrophosphatase (ITPA), Recombinant Protein - MBS1446659 from MyBioSource
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