| Gene Symbol | CDC5L |
|---|---|
| Entrez Gene | 988 |
| Alt Symbol | CDC5, CDC5-LIKE, CEF1, PCDC5RP, dJ319D22.1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | cell division cycle 5-like |
| Other Description | CDC5 cell division cycle 5-like|Cdc5-related protein|cell division cycle 5-like protein|dJ319D22.1 (CDC5-like protein)|pombe cdc5-related protein |
| Swissprots | Q76N46 Q99459 Q99974 |
| Accessions | AAR89913 EAX04270 Q99459 AB007892 BAA24862 AK128737 BAG54722 AK299738 BAG61633 BC001568 AAH01568 BG187521 BG497404 BM829346 D85423 BAA20885 DC422730 DQ891623 ABM82549 DQ894814 ABM85740 U86753 AAB61210 XM_006715289 XP_006715352 XR_926346 NM_001253 NP_001244 |
| Function | DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR). {ECO:0000269|PubMed:10570151, ECO:0000269|PubMed:11082045, ECO:0000269|PubMed:11101529, ECO:0000269|PubMed:11544257, ECO:0000269|PubMed:12927788, ECO:0000269|PubMed:18583928, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:9038199, ECO:0000269|PubMed:9468527, ECO:0000269|PubMed:9632794}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:10570151, ECO:0000269|PubMed:11544257, ECO:0000269|PubMed:18583928, ECO:0000269|PubMed:9038199, ECO:0000269|PubMed:9598309}. Nucleus speckle {ECO:0000269|PubMed:10570151, ECO:0000269|PubMed:10827081, ECO:0000269|PubMed:11544257}. Cytoplasm {ECO:0000269|PubMed:9038199}. Note=May shuttle between cytoplasm and nucleus. {ECO:0000269|PubMed:9038199}. |
| Tissue Specificity | Ubiquitously expressed in both fetal and adult tissues. {ECO:0000269|PubMed:9038199, ECO:0000269|PubMed:9598309, ECO:0000269|PubMed:9632794}. |
| Top Pathways | Spliceosome |