Gene Symbol | CDC5L |
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Entrez Gene | 988 |
Alt Symbol | CDC5, CDC5-LIKE, CEF1, PCDC5RP, dJ319D22.1 |
Species | Human |
Gene Type | protein-coding |
Description | cell division cycle 5-like |
Other Description | CDC5 cell division cycle 5-like|Cdc5-related protein|cell division cycle 5-like protein|dJ319D22.1 (CDC5-like protein)|pombe cdc5-related protein |
Swissprots | Q76N46 Q99459 Q99974 |
Accessions | AAR89913 EAX04270 Q99459 AB007892 BAA24862 AK128737 BAG54722 AK299738 BAG61633 BC001568 AAH01568 BG187521 BG497404 BM829346 D85423 BAA20885 DC422730 DQ891623 ABM82549 DQ894814 ABM85740 U86753 AAB61210 XM_006715289 XP_006715352 XR_926346 NM_001253 NP_001244 |
Function | DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR). {ECO:0000269|PubMed:10570151, ECO:0000269|PubMed:11082045, ECO:0000269|PubMed:11101529, ECO:0000269|PubMed:11544257, ECO:0000269|PubMed:12927788, ECO:0000269|PubMed:18583928, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:9038199, ECO:0000269|PubMed:9468527, ECO:0000269|PubMed:9632794}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:10570151, ECO:0000269|PubMed:11544257, ECO:0000269|PubMed:18583928, ECO:0000269|PubMed:9038199, ECO:0000269|PubMed:9598309}. Nucleus speckle {ECO:0000269|PubMed:10570151, ECO:0000269|PubMed:10827081, ECO:0000269|PubMed:11544257}. Cytoplasm {ECO:0000269|PubMed:9038199}. Note=May shuttle between cytoplasm and nucleus. {ECO:0000269|PubMed:9038199}. |
Tissue Specificity | Ubiquitously expressed in both fetal and adult tissues. {ECO:0000269|PubMed:9038199, ECO:0000269|PubMed:9598309, ECO:0000269|PubMed:9632794}. |
Top Pathways | Spliceosome |
Human CDC5L full length protein - ab132350 from Abcam
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Human CDC5L peptide - ab30674 from Abcam
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Human CDC5L protein fragment - ab158071 from Abcam
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CDC5 / CDC5L Antibody Blocking Peptide - LS-E14701 from LifeSpan Bioscience
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CDC5 / CDC5L Antibody Blocking Peptide - LS-E9868 from LifeSpan Bioscience
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Recombinant Human CDC5L Protein - H00000988-P01 from Novus Biologicals
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Recombinant Human CDC5L Protein - H00000988-Q01 from Novus Biologicals
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CDC5L-Antibody-Center-Blocking-Peptide - BP8949c from Abgent, a WuXi AppTec company
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CDC5L Blocking Peptide - 33R-5034 from Fitzgerald
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CDC5L - H00000988-P01 from Acris Antibodies
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CDC5L - H00000988-Q01-10 from Acris Antibodies
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CDC5L - H00000988-Q01-25 from Acris Antibodies
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CDC5L fusion protein - Ag3578 from Proteintech Group
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Recombinant Human CDC5L, GST-tagged - CDC5L-11017H from Creative Biomart
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Recombinant Human Cell division cycle 5-like protein(CDC5L) ,partial - CSB-YP858712HU CSB-EP858712HU CSB-BP858712HU CSB-MP858712HU from Cusabio
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CDC5L - TP301702 from Acris Antibodies
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Cell division cycle 5-like protein (CDC5L), partial, Recombinant Protein - MBS1434047 from MyBioSource
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CDC5L Recombinant Protein Antigen - NBP1-85720PEP from Novus Biologicals
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CDC5L Recombinant Protein Antigen - NBP1-85719PEP from Novus Biologicals
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CDC5L Peptide, Human - M34GP02817H from Creative Peptides
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