CDC5L

Gene Symbol	CDC5L
Entrez Gene	988
Alt Symbol	CDC5, CDC5-LIKE, CEF1, PCDC5RP, dJ319D22.1
Species	Human
Gene Type	protein-coding
Description	cell division cycle 5-like
Other Description	CDC5 cell division cycle 5-like\|Cdc5-related protein\|cell division cycle 5-like protein\|dJ319D22.1 (CDC5-like protein)\|pombe cdc5-related protein
Swissprots	Q76N46 Q99459 Q99974
Accessions	AAR89913 EAX04270 Q99459 AB007892 BAA24862 AK128737 BAG54722 AK299738 BAG61633 BC001568 AAH01568 BG187521 BG497404 BM829346 D85423 BAA20885 DC422730 DQ891623 ABM82549 DQ894814 ABM85740 U86753 AAB61210 XM_006715289 XP_006715352 XR_926346 NM_001253 NP_001244
Function	DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR). {ECO:0000269\|PubMed:10570151, ECO:0000269\|PubMed:11082045, ECO:0000269\|PubMed:11101529, ECO:0000269\|PubMed:11544257, ECO:0000269\|PubMed:12927788, ECO:0000269\|PubMed:18583928, ECO:0000269\|PubMed:24332808, ECO:0000269\|PubMed:9038199, ECO:0000269\|PubMed:9468527, ECO:0000269\|PubMed:9632794}.
Subcellular Location	Nucleus {ECO:0000269\|PubMed:10570151, ECO:0000269\|PubMed:11544257, ECO:0000269\|PubMed:18583928, ECO:0000269\|PubMed:9038199, ECO:0000269\|PubMed:9598309}. Nucleus speckle {ECO:0000269\|PubMed:10570151, ECO:0000269\|PubMed:10827081, ECO:0000269\|PubMed:11544257}. Cytoplasm {ECO:0000269\|PubMed:9038199}. Note=May shuttle between cytoplasm and nucleus. {ECO:0000269\|PubMed:9038199}.
Tissue Specificity	Ubiquitously expressed in both fetal and adult tissues. {ECO:0000269\|PubMed:9038199, ECO:0000269\|PubMed:9598309, ECO:0000269\|PubMed:9632794}.
Top Pathways	Spliceosome

Cdc5L (D-11) - sc-398280 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

Cdc5L (D-11): sc-398280. Western blot analysis of Cdc5L expression in HeLa (A) and Jurkat (B) whole cell lysates and human cerebellum tissue extract (C).

Cdc5L (H-300) - sc-292706 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

Cdc5L (L-20) - sc-68270 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Cdc5L (21) - sc-135863 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	50 µg/0.5 ml
Host	Mouse
Clonality	Monoclonal

Cdc5L (21): sc-135863. Western blot analysis of Cdc5L expression in rat cerebrum tissue extract.

Cdc5L (2136C1a) - sc-81220 from Santa Cruz Biotechnology

Prices	$295.00
Sizes	100 µg/ml
Host	Mouse
Clonality	Monoclonal

ZnT-9 (919C1a): sc-81118 Western Blot analysis of human recombinant ZnT-9 fusion protein.

Anti-CDC5L antibody - ab31779 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-CDC5L antibody (ab31779) at 1 µg/mlLane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate Lane 2 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell Lysate (ab7899)Lane 3 : A431 (Human epithelial carcinoma cell line) Whole Cell Lysate (ab7909)Lysates/proteins at 20 µg per lane.SecondaryGoat polyclonal to Rabbit IgG (Alexa Fluor® 680) at 1/10000 dilutionPerformed under reducing conditions.

Anti-CDC5L antibody - ab187174 from Abcam

Prices	$376.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-CDC5L antibody (ab187174) at 1/500 dilutionLane 1 : MCF-7 cell extractLane 2 : THP-1 cell extractLane 3 : K562 cell extractLane 4 : SW480 cell extractLane 5 : Mouse spleen extractLane 6 : Mouse thymus extractLane 7 : Mouse testis extract

Anti-CDC5L antibody [2136C1a] - ab51320 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	2136C1a

Anti-CDC5L antibody [2136C1a] (ab51320) at 1/100 dilution + HeLa whole cell lysate at 50 µgSecondaryanti-mouse IgG at 1/2500 dilutiondeveloped using the ECL technique

Anti-CDC5L antibody [EPR7658] - ab129114 from Abcam

Prices	$313.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR7658

All lanes : Anti-CDC5L antibody [EPR7658] (ab129114) at 1/1000 dilutionLane 1 : Fetal brain lysateLane 2 : HeLa cell lysateLysates/proteins at 10 µg per lane.SecondaryStandard HRP labelled goat anti-rabbit at 1/2000 dilution

Anti-CDC5 / CDC5L Antibody - LS-C78923 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Mouse
Clonality	Monoclonal

Anti-CDC5 / CDC5L Antibody (Internal, APC) - LS-C254289 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CDC5 / CDC5L Antibody (Internal, Biotin) - LS-C254291 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CDC5 / CDC5L Antibody (Internal, AP) - LS-C254290 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CDC5 / CDC5L Antibody (Internal, FITC) - LS-C254293 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CDC5 / CDC5L Antibody (Internal, PE) - LS-C254295 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CDC5 / CDC5L Antibody (Internal, Azide-free, HRP) - LS-C254294 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CDC5 / CDC5L Antibody (aa721-770) - LS-C291272 from LifeSpan Bioscience

Prices	$315.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-CDC5 / CDC5L Antibody (aa100-150) - LS-C288467 from LifeSpan Bioscience

Prices	$375.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CDC5 / CDC5L Antibody (C-Terminus) - LS-C101835 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

CDC5L antibody LS-C101835 Western blot of 721_B cell lysate.

Anti-CDC5 / CDC5L Antibody (clone 2136C1a) - LS-C184361 from LifeSpan Bioscience

Prices	$335.00
Sizes	50 µg
Host	Mouse
Clonality	Monoclonal
Clone	2136C1a

Immunofluorescent staining using CDC5L antibody. Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.01% Triton-X100 in PBS. The cells were immunostained with anti-CDC5L antibody.

Anti-CDC5 / CDC5L Antibody - LS-C341656 from LifeSpan Bioscience

Prices	$385.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-CDC5 / CDC5L Antibody (Internal) - LS-C320239 from LifeSpan Bioscience

Prices	$345.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CDC5 / CDC5L Antibody (aa752-802) - LS-C288469 from LifeSpan Bioscience

Prices	$375.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Detection of Human CDC5L by Immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-CDC5L used at a dilution of 1:200 (1 ug/ml).

Anti-CDC5 / CDC5L Antibody (Internal, clone EPR7658) - LS-C152565 from LifeSpan Bioscience

Prices	$395.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR7658

IHC of paraffin-embedded human kidney tissue using anti-CDC5L antibody.

Anti-CDC5 / CDC5L Antibody (clone 3C12) - LS-C196870 from LifeSpan Bioscience

Prices	$355.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	3C12

Western Blot analysis of CDC5L expression in transfected 293T cell line by CDC5L monoclonal antibody (M08), clone 3C12.Lane 1: CDC5L transfected lysate(92.3 KDa).Lane 2: Non-transfected lysate.

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