| Gene Symbol |
TOPBP1
|
| Entrez Gene |
11073
|
| Alt Symbol |
TOP2BP1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
topoisomerase (DNA) II binding protein 1
|
| Other Description |
DNA topoisomerase 2-binding protein 1|DNA topoisomerase II-beta-binding protein 1|DNA topoisomerase II-binding protein 1
|
| Swissprots |
Q7LGC1 Q92547 B7Z7W8 Q9UEB9
|
| Accessions |
EAW79173 EAW79174 EAW79175 Q92547 AB019397 BAA34202 AK026229 AK302584 BAH13754 BC017552 BC032633 AAH32633 BC126209 AAI26210 BC151237 AAI51238 D87448 BAA13389 Y18557 XM_005247076 XP_005247133 XM_011512357 XP_011510659 NM_007027 NP_008958
|
| Function |
Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double- stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1- responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR. {ECO:0000269|PubMed:10498869, ECO:0000269|PubMed:11395493, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:12697828, ECO:0000269|PubMed:15075294, ECO:0000269|PubMed:16530042}.
|
| Subcellular Location |
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Chromosome. Note=Detected on unpaired autosomes in meiotic prophase cells. Detected on X and Y chromosomes during later stages of prophase. Colocalizes with ATR and H2AFX at unsynapsed chromosome cores during prophase (By similarity). Has a uniform nuclear distribution during G phase. Colocalizes with BRCA1 at stalled replication forks during S phase. In mitotic cells it colocalizes with BRCA1 at spindle poles and centrosomes during metaphase and anaphase. Detected in discrete foci together with PML and numerous DNA repair enzymes after DNA damage by alkylating agents, UV or gamma irradiation. Localizes to sites of DNA damage in a H2AX- independent manner. {ECO:0000250}.
|
| Tissue Specificity |
Highly expressed in heart, brain, placenta, lung and kidney. {ECO:0000269|PubMed:9461304}.
|
