| Gene Symbol | TUBB3 |
|---|---|
| Entrez Gene | 10381 |
| Alt Symbol | CDCBM, CDCBM1, CFEOM3, CFEOM3A, FEOM3, TUBB4, beta-4 |
| Species | Human |
| Gene Type | protein-coding |
| Description | tubulin, beta 3 class III |
| Other Description | class III beta-tubulin|tubulin beta-3 chain|tubulin beta-4 chain|tubulin beta-III |
| Swissprots | Q9BTZ0 A8K854 Q9BW10 Q13509 |
| Accessions | EAW66669 EAW66674 EAW66675 Q13509 AF427491 AAL28094 AK058140 AK122757 BAG53710 AK127418 AK223039 BAD96759 AK292219 BAF84908 AK307201 AK314616 BAG37182 AU142509 BC000748 AAH00748 BC001678 AAH01678 BC003021 AAH03021 BC047518 AAH47518 BC064975 CD621827 DA054466 S62643 U47634 AAC52035 NM_001197181 NP_001184110 NM_006086 NP_006077 |
| Function | Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. TUBB3 plays a critical role in proper axon guidance and mantainance. {ECO:0000269|PubMed:20074521}. |
| Subcellular Location | Cytoplasm, cytoskeleton. |
| Tissue Specificity | Expression is primarily restricted to central and peripheral nervous system. Greatly increased expression in most cancerous tissues. {ECO:0000269|PubMed:14736079, ECO:0000269|PubMed:20191564}. |
| Top Pathways | Gap junction, Pathogenic Escherichia coli infection, Phagosome |