Gene Symbol | ING1 |
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Entrez Gene | 3621 |
Alt Symbol | p24ING1c, p33, p33ING1, p33ING1b, p47, p47ING1a |
Species | Human |
Gene Type | protein-coding |
Description | inhibitor of growth family, member 1 |
Other Description | growth inhibitor ING1|growth inhibitory protein ING1|inhibitor of growth protein 1|tumor suppressor ING1 |
Swissprots | Q9UIJ3 Q9UBC6 Q9UIJ4 Q5T9H1 Q9UK52 Q9NS83 O43658 Q5T9G8 O00532 Q9UIJ2 Q9HD98 Q9P0U6 Q5T9G9 Q9HD99 Q9UIJ1 Q5T9H0 Q53ZR3 Q9H007 Q9UK53 |
Accessions | AAG02578 AAG02579 AAG12175 BAA82888 BAA82889 BAA82890 BAA83462 BAB08101 BAB08102 BAB08103 CBX53821 CBX53822 CBX53823 CBX53824 EAX09127 EAX09128 EAX09129 EAX09130 EAX09131 Q9UK53 AA450055 AB024401 BAA82886 AB024402 BAA82887 AB031269 BAA83496 AB037594 BAB20992 AF001954 AAB60879 AF044076 AAC00501 AF078835 AAG12174 AF149721 AAF37421 AF149722 AAF37422 AF149723 AAF37423 AF181849 AAF07920 AF181850 AAF07921 AI016573 AJ310392 CAC38067 AK302353 BAG63679 BC018348 BC093942 AAH93942 BC093944 AAH93944 BF435293 BF510437 BG703874 BQ430264 DB450867 DB537640 NM_001267728 NP_001254657 NM_005537 NP_005528 NM_198217 NP_937860 NM_198218 NP_937861 NM_198219 NP_937862 |
Function | Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene. {ECO:0000269|PubMed:9440695}. |
Subcellular Location | Nucleus {ECO:0000305}. |
Tissue Specificity | Isoform 2 was expressed in all normal tissues and cells examined, as well as in all breast cancer and melanoma cell lines examined. Isoform 3 was expressed in testis, liver, and kidney, weakly expressed in colon and brain and not expressed in breast and cultured melanocytes. Isoform 4 was highly expressed in testis and weakly expressed in brain, but not expressed in breast, colon, kidney, melanocytes, breast cancer or melanoma cell lines. {ECO:0000269|PubMed:10626813}. |
ING1 CRISPR/Cas9 KO Plasmid (h) - sc-402893 from Santa Cruz Biotechnology
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ING1 HDR Plasmid (h) - sc-402893-HDR from Santa Cruz Biotechnology
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ING1 Double Nickase Plasmid (h) - sc-402893-NIC from Santa Cruz Biotechnology
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ING1 Double Nickase Plasmid (h2) - sc-402893-NIC-2 from Santa Cruz Biotechnology
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ING1 CRISPR Activation Plasmid (h) - sc-402893-ACT from Santa Cruz Biotechnology
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ING1 CRISPR Activation Plasmid (h2) - sc-402893-ACT-2 from Santa Cruz Biotechnology
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ING1 Lentiviral Activation Particles (h) - sc-402893-LAC from Santa Cruz Biotechnology
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ING1 Lentiviral Activation Particles (h2) - sc-402893-LAC-2 from Santa Cruz Biotechnology
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ING1 siRNA (h) - sc-36152 from Santa Cruz Biotechnology
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ING1 shRNA Plasmid (h) - sc-36152-SH from Santa Cruz Biotechnology
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ING1 shRNA (h) Lentiviral Particles - sc-36152-V from Santa Cruz Biotechnology
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ING1 RNAi - H00003621-R03 from Novus Biologicals
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ING1 RNAi - H00003621-R04 from Novus Biologicals
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ING1 RNAi - H00003621-R01 from Novus Biologicals
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ING1 RNAi - H00003621-R02 from Novus Biologicals
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MISSION® esiRNA - EHU140461 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10670 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10670 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08151 from Sigma-Aldrich
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ING1 siRNA (Human) - CRH2425 from Cohesion Biosciences
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ING1 - MBS8231878 from MyBioSource
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shRNA set against Human ING1 (NM_005537.4) - SHH319469 from Creative biogene
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Human ING1 siRNA - orb262927 from Biorbyt
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ING1 shRNA Plasmid (Human) - CHH2425 from Cohesion Biosciences
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ING1 miRNA 3'UTR clone - MiUTR3H-04210 from Creative biogene
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