Gene Symbol | AANAT |
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Entrez Gene | 15 |
Alt Symbol | DSPS, SNAT |
Species | Human |
Gene Type | protein-coding |
Description | aralkylamine N-acetyltransferase |
Other Description | arylalkylamine N-acetyltransferase|serotonin N-acetyltransferase|serotonin acetylase |
Swissprots | A0AVF2 Q16613 Q562F4 J3KMZ5 |
Accessions | AAC50555 AAK49981 BAB20312 BAB20313 BAB20314 BAB20315 BAB20316 EAW89400 Q16613 AA084486 AB593119 BAJ84059 AI819939 AY055827 BC069434 AAH69434 BC092430 AAH92430 BC126332 AAI26333 BC126334 AAI26335 BC143989 HQ448439 ADQ32919 U40347 AAC50554 XM_011524415 XP_011522717 XM_011524416 XP_011522718 XM_011524417 XP_011522719 XM_011524418 XP_011522720 XM_011524419 XP_011522721 XM_011524420 XP_011522722 XM_011524421 XP_011522723 XM_011524422 XP_011522724 XM_011524423 XP_011522725 NM_001088 NP_001079 NM_001166579 NP_001160051 NR_110548 |
Function | Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N- acetylserotonin, the penultimate step in the synthesis of melatonin. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:11313340}. |
Tissue Specificity | Highly expressed in pineal gland and at lower levels in the retina. Weak expression in several brain regions and in the pituitary gland. {ECO:0000269|PubMed:18212399, ECO:0000269|PubMed:8661026}. |
Top Pathways | Tryptophan metabolism |
AANAT CRISPR/Cas9 KO Plasmid (h) - sc-403080 from Santa Cruz Biotechnology
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AANAT HDR Plasmid (h) - sc-403080-HDR from Santa Cruz Biotechnology
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AANAT Double Nickase Plasmid (h) - sc-403080-NIC from Santa Cruz Biotechnology
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AANAT Double Nickase Plasmid (h2) - sc-403080-NIC-2 from Santa Cruz Biotechnology
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AANAT CRISPR Activation Plasmid (h) - sc-403080-ACT from Santa Cruz Biotechnology
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AANAT CRISPR Activation Plasmid (h2) - sc-403080-ACT-2 from Santa Cruz Biotechnology
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AANAT Lentiviral Activation Particles (h) - sc-403080-LAC from Santa Cruz Biotechnology
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AANAT Lentiviral Activation Particles (h2) - sc-403080-LAC-2 from Santa Cruz Biotechnology
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AANAT siRNA (h) - sc-61928 from Santa Cruz Biotechnology
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AANAT shRNA Plasmid (h) - sc-61928-SH from Santa Cruz Biotechnology
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AANAT shRNA (h) Lentiviral Particles - sc-61928-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN2610 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2610 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01074 from Sigma-Aldrich
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AANAT siRNA (Human) - CRH0008 from Cohesion Biosciences
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AANAT - MBS8216128 from MyBioSource
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shRNA set against Human AANAT (NM_001088.2) - SHH228626 from Creative biogene
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AANAT shRNA Plasmid (Human) - CHH0008 from Cohesion Biosciences
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AANAT miRNA 3'UTR clone - MiUTR4H-TG00011 from Creative biogene
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