EPRS

Gene Symbol	EPRS
Entrez Gene	2058
Alt Symbol	EARS, GLUPRORS, PARS, PIG32, QARS, QPRS
Species	Human
Gene Type	protein-coding
Description	glutamyl-prolyl-tRNA synthetase
Other Description	bifunctional aminoacyl-tRNA synthetase|bifunctional glutamate/proline--tRNA ligase|cell proliferation-inducing gene 32 protein|glutamate tRNA ligase|glutamatyl-prolyl-tRNA synthetase|glutaminyl-tRNA synthetase|proliferation-inducing gene 32 protein|proliferation-inducing protein 32|proline tRNA ligase|proline-tRNA ligase|prolyl-tRNA synthetase
Swissprots	B9EGH3 Q5H9S5 A0AVA9 Q6PD57 Q05BP6 Q5DSM1 Q05DF8 Q86X73 P07814
Accessions	EAW93309 EAW93310 P07814 AA196283 AK296755 BAG59337 AK298192 BAG60462 AK307534 AY493416 AAS72877 BC015494 AAH15494 BC034797 AAH34797 BC046156 AAH46156 BC058921 AAH58921 BC067841 BC105983 AAI05984 BC126275 AAI26276 BC136465 AAI36466 CR933648 CAI45949 JQ080075 AFA28127 N85252 X07466 CAA30354 X54326 CAA38224 NM_004446 NP_004437
Function	Catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the multisynthetase complex and assembles into the GAIT complex which binds to stem loop- containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. {ECO:0000269|PubMed:15479637, ECO:0000269|PubMed:1756734, ECO:0000269|PubMed:23071094}.
Subcellular Location	Cytoplasm {ECO:0000305}.
Top Pathways	Porphyrin and chlorophyll metabolism, Aminoacyl-tRNA biosynthesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Prolyl-tRNA synthetase protein - ab185601 from Abcam Category Protein Source E. coli Species Human

EPRS / PARS Antibody Blocking Peptide - LS-E16809 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EPRS / PARS Antibody Blocking Peptide - LS-E16810 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EPRS / PARS Antibody Blocking Peptide - LS-E9060 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EPRS Peptide - P2578 from Novus Biologicals Category Peptide Species Human

EPRS-Antibody-N-term-Blocking-Peptide - BP7565a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

EPRS Blocking Peptide - 33R-3367 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

EPRS Blocking Peptide - 33R-4645 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

EPRS fusion protein - Ag19184 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

EPRS fusion protein - Ag18011 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human EPRS, GST-tagged - EPRS-12504H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Bifunctional glutamate/proline--tRNA ligase(EPRS) ,partial - CSB-YP007747HU CSB-EP007747HU CSB-BP007747HU CSB-MP007747HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

EPRS - TP317559 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Recombinant Glutamyl Prolyl tRNA Synthetase (EPRS) - RPD008Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Glutamyl Prolyl tRNA Synthetase (EPRS) - RPD008Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

EPRS Recombinant Protein Antigen - NBP1-84930PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

EPRS Recombinant Protein Antigen - NBP1-84929PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

EPRS Peptide, Human - M34GP05011H from Creative Peptides Category Peptide Source Synthetic. Species Human

EPRS Recombinant Protein (OPCD00359) - OPCD00359 from Aviva Systems Biology Category Protein Source E.coli Species Human

Bifunctional glutamate/proline--tRNA ligase (EPRS), partial, Recombinant Protein - MBS956843 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Glutamyl Prolyl tRNA Synthetase, Recombinant Protein - MBS2034292 from MyBioSource Category Protein Prices $185.00, $375.00, $580.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic Expression Species Mouse

Glutamyl Prolyl tRNA Synthetase, Recombinant Protein - MBS2034128 from MyBioSource Category Protein Prices $170.00, $350.00, $545.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic Expression Species Human

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