EPRS

Gene Symbol EPRS
Entrez Gene 2058
Alt Symbol EARS, GLUPRORS, PARS, PIG32, QARS, QPRS
Species Human
Gene Type protein-coding
Description glutamyl-prolyl-tRNA synthetase
Other Description bifunctional aminoacyl-tRNA synthetase|bifunctional glutamate/proline--tRNA ligase|cell proliferation-inducing gene 32 protein|glutamate tRNA ligase|glutamatyl-prolyl-tRNA synthetase|glutaminyl-tRNA synthetase|proliferation-inducing gene 32 protein|proliferation-inducing protein 32|proline tRNA ligase|proline-tRNA ligase|prolyl-tRNA synthetase
Swissprots B9EGH3 Q5H9S5 A0AVA9 Q6PD57 Q05BP6 Q5DSM1 Q05DF8 Q86X73 P07814
Accessions EAW93309 EAW93310 P07814 AA196283 AK296755 BAG59337 AK298192 BAG60462 AK307534 AY493416 AAS72877 BC015494 AAH15494 BC034797 AAH34797 BC046156 AAH46156 BC058921 AAH58921 BC067841 BC105983 AAI05984 BC126275 AAI26276 BC136465 AAI36466 CR933648 CAI45949 JQ080075 AFA28127 N85252 X07466 CAA30354 X54326 CAA38224 NM_004446 NP_004437
Function Catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the multisynthetase complex and assembles into the GAIT complex which binds to stem loop- containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. {ECO:0000269|PubMed:15479637, ECO:0000269|PubMed:1756734, ECO:0000269|PubMed:23071094}.
Subcellular Location Cytoplasm {ECO:0000305}.
Top Pathways Porphyrin and chlorophyll metabolism, Aminoacyl-tRNA biosynthesis

ProRS CRISPR/Cas9 KO Plasmid (h) - sc-407542 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ProRS HDR Plasmid (h) - sc-407542-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ProRS Double Nickase Plasmid (h) - sc-407542-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ProRS Double Nickase Plasmid (h2) - sc-407542-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ProRS CRISPR Activation Plasmid (h) - sc-407542-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ProRS CRISPR Activation Plasmid (h2) - sc-407542-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ProRS Lentiviral Activation Particles (h) - sc-407542-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ProRS Lentiviral Activation Particles (h2) - sc-407542-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ProRS siRNA (h) - sc-76254 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ProRS shRNA Plasmid (h) - sc-76254-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ProRS shRNA (h) Lentiviral Particles - sc-76254-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU002081 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN7932 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7932 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

EPRS siRNA (Human) - CRH1435 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

EPRS - MBS8239057 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human EPRS (NM_004446.2) - SHH286637 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human EPRS(NM_004446.2) - SHH037019 from Creative biogene

Category siRNA
Species Reactivities Human

Human EPRS siRNA - orb261937 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

EPRS shRNA Plasmid (Human) - CHH1435 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

EPRS miRNA 3'UTR clone - MiUTR1H-03276 from Creative biogene

Species Reactivities Human
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