Gene Symbol | FRMD7 |
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Entrez Gene | 90167 |
Alt Symbol | NYS, NYS1, XIPAN |
Species | Human |
Gene Type | protein-coding |
Description | FERM domain containing 7 |
Other Description | FERM domain-containing protein 7 |
Swissprots | C0LLJ3 Q6ZUT3 Q5JX99 |
Accessions | EAX11785 Q6ZUT3 AI492387 AK125336 BAC86135 AL161984 BC114371 AAI14372 DB511321 FJ717411 ACN56448 XM_005262493 XP_005262550 NM_001306193 NP_001293122 NM_194277 NP_919253 |
Function | Plays a role in neurite development, may be through the activation of the GTPase RAC1. Plays a role in the control of eye movement and gaze stability. {ECO:0000250|UniProtKB:A2AD83, ECO:0000269|PubMed:17013395, ECO:0000269|PubMed:23946638}. |
Subcellular Location | Cell projection {ECO:0000250|UniProtKB:A2AD83}. Cell projection, growth cone {ECO:0000250|UniProtKB:A2AD83}. Note=In undifferentiated neurons, located in the actin-rich regions of the cell body. In differentiated neurons, located in the actin-rich regions of the cell body and primary neurite processes but is almost absent from secondary extensions arising from the primary neurite. Also found at the actin-rich distal end of growth cones (By similarity). {ECO:0000250|UniProtKB:A2AD83}. |
Tissue Specificity | Expressed in liver, kidney, pancreas and at low levels in brain and heart. Expressed in embryonic brain and developing neural retina. {ECO:0000269|PubMed:17013395}. |
FRMD7 CRISPR/Cas9 KO Plasmid (h) - sc-409350 from Santa Cruz Biotechnology
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FRMD7 HDR Plasmid (h) - sc-409350-HDR from Santa Cruz Biotechnology
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FRMD7 Double Nickase Plasmid (h) - sc-409350-NIC from Santa Cruz Biotechnology
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FRMD7 Double Nickase Plasmid (h2) - sc-409350-NIC-2 from Santa Cruz Biotechnology
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FRMD7 CRISPR Activation Plasmid (h) - sc-409350-ACT from Santa Cruz Biotechnology
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FRMD7 CRISPR Activation Plasmid (h2) - sc-409350-ACT-2 from Santa Cruz Biotechnology
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FRMD7 Lentiviral Activation Particles (h) - sc-409350-LAC from Santa Cruz Biotechnology
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FRMD7 Lentiviral Activation Particles (h2) - sc-409350-LAC-2 from Santa Cruz Biotechnology
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FRMD7 siRNA (h) - sc-91037 from Santa Cruz Biotechnology
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FRMD7 shRNA Plasmid (h) - sc-91037-SH from Santa Cruz Biotechnology
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FRMD7 shRNA (h) Lentiviral Particles - sc-91037-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU010581 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN8948 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8948 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07226 from Sigma-Aldrich
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FRMD7 siRNA (Human) - CRJ3910 from Cohesion Biosciences
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FRMD7 - MBS8209546 from MyBioSource
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shRNA set against Human FRMD7 (NM_194277.2) - SHH297169 from Creative biogene
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Human FRMD7 siRNA - orb274411 from Biorbyt
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FRMD7 shRNA Plasmid (Human) - CHJ3910 from Cohesion Biosciences
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FRMD7 miRNA 3'UTR clone - MiUTR4H-TG03637 from Creative biogene
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