Gene Symbol | IGSF1 |
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Entrez Gene | 3547 |
Alt Symbol | CHTE, IGCD1, IGDC1, INHBP, PGSF2, p120 |
Species | Human |
Gene Type | protein-coding |
Description | immunoglobulin superfamily, member 1 |
Other Description | immunoglobulin superfamily member 1|immunoglobulin-like domain-containing protein 1|inhibin-binding protein|pituitary gland-specific factor 2 |
Swissprots | Q8N6C5 B5MEG2 Q9NTC8 O15070 H9KV64 |
Accessions | CBJ05779 CBJ21231 EAX11791 EAX11792 Q8N6C5 AB058894 BAB40235 AF034198 AAC52057 AK057916 AK226008 AK295438 BAG58378 AK307871 AL137369 CAB70713 AM392808 CAL37686 AM393117 CAL37995 AM393328 CAL38206 AM393390 CAL38268 BC028312 BC063884 AAH63884 DA195297 Y10523 CAA71535 XM_011531330 XP_011529632 XM_011531331 XP_011529633 XM_011531332 XP_011529634 XM_011531333 XP_011529635 XM_011531334 XP_011529636 XM_011531335 XP_011529637 NM_001170961 NP_001164432 NM_001170962 NP_001164433 NM_001170963 NP_001164434 NM_001555 NP_001546 NM_205833 NP_991402 |
Function | Seems to be a coreceptor in inhibin signaling, but seems not to be a high-affinity inhibin receptor. Antagonizes activin A signaling in the presence or absence of inhibin B (By similarity). Necessary to mediate a specific antagonistic effect of inhibin B on activin-stimulated transcription. {ECO:0000250, ECO:0000269|PubMed:11266516}. |
Subcellular Location | Isoform 3: Secreted {ECO:0000305}. |
Tissue Specificity | Highly expressed in pancreas, testis and fetal liver. Moderately expressed in heart, prostate and small intestine. Expressed at very low levels in brain, thymus, ovary, colon, fetal lung and fetal kidney. Expressed in muscle. Isoform 3 is expressed in pituitary gland. {ECO:0000269|PubMed:11854097, ECO:0000269|PubMed:23143598, ECO:0000269|PubMed:9521868}. |
Human IGSF1 full length protein - ab158752 from Abcam
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Human IGSF1 protein fragment - ab158753 from Abcam
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IGSF1 Antibody Blocking Peptide - LS-E448 from LifeSpan Bioscience
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IGSF1 Antibody Blocking Peptide - LS-E15740 from LifeSpan Bioscience
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IGSF1 Antibody Blocking Peptide - LS-E15444 from LifeSpan Bioscience
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IGSF1 Antibody Blocking Peptide - LS-E15445 from LifeSpan Bioscience
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Recombinant Human IGSF1 Protein - H00003547-Q01 from Novus Biologicals
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Recombinant Human IGSF1 Protein - H00003547-P01 from Novus Biologicals
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IGSF1-Antibody-C-term-Blocking-peptide - BP10732b from Abgent, a WuXi AppTec company
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IGSF1 Blocking Peptide - 33R-9971 from Fitzgerald
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IGSF1 Blocking Peptide - 33R-9197 from Fitzgerald
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IGSF1 Blocking Peptide - 33R-4821 from Fitzgerald
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IGSF1 Blocking Peptide - 33R-7329 from Fitzgerald
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IGSF1 / PGSF2 - H00003547-P01-10 from Acris Antibodies
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IGSF1 / PGSF2 - H00003547-P01-25 from Acris Antibodies
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IGSF1 / PGSF2 - H00003547-Q01-10 from Acris Antibodies
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IGSF1 / PGSF2 - H00003547-Q01-25 from Acris Antibodies
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IGSF1 fusion protein - ag12286 from Proteintech Group
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IGSF1 fusion protein - ag12421 from Proteintech Group
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Recombinant Inhibin Binding Protein (INHBP) - RPA273Hu01 from Uscn Life Science Inc.
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Recombinant Inhibin Binding Protein (INHBP) - RPA273Mu01 from Uscn Life Science Inc.
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Recombinant Inhibin Binding Protein (INHBP) - RPA273Ra01 from Uscn Life Science Inc.
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Recombinant Inhibin Binding Protein (INHBP) - RPA273Hu01 from Cloud-clone
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IGSF1 Recombinant Protein Antigen - NBP2-14119PEP from Novus Biologicals
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IGSF1 Peptide, Human - M34GP07504H from Creative Peptides
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