Gene Symbol | IGSF1 |
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Entrez Gene | 3547 |
Alt Symbol | CHTE, IGCD1, IGDC1, INHBP, PGSF2, p120 |
Species | Human |
Gene Type | protein-coding |
Description | immunoglobulin superfamily, member 1 |
Other Description | immunoglobulin superfamily member 1|immunoglobulin-like domain-containing protein 1|inhibin-binding protein|pituitary gland-specific factor 2 |
Swissprots | Q8N6C5 B5MEG2 Q9NTC8 O15070 H9KV64 |
Accessions | CBJ05779 CBJ21231 EAX11791 EAX11792 Q8N6C5 AB058894 BAB40235 AF034198 AAC52057 AK057916 AK226008 AK295438 BAG58378 AK307871 AL137369 CAB70713 AM392808 CAL37686 AM393117 CAL37995 AM393328 CAL38206 AM393390 CAL38268 BC028312 BC063884 AAH63884 DA195297 Y10523 CAA71535 XM_011531330 XP_011529632 XM_011531331 XP_011529633 XM_011531332 XP_011529634 XM_011531333 XP_011529635 XM_011531334 XP_011529636 XM_011531335 XP_011529637 NM_001170961 NP_001164432 NM_001170962 NP_001164433 NM_001170963 NP_001164434 NM_001555 NP_001546 NM_205833 NP_991402 |
Function | Seems to be a coreceptor in inhibin signaling, but seems not to be a high-affinity inhibin receptor. Antagonizes activin A signaling in the presence or absence of inhibin B (By similarity). Necessary to mediate a specific antagonistic effect of inhibin B on activin-stimulated transcription. {ECO:0000250, ECO:0000269|PubMed:11266516}. |
Subcellular Location | Isoform 3: Secreted {ECO:0000305}. |
Tissue Specificity | Highly expressed in pancreas, testis and fetal liver. Moderately expressed in heart, prostate and small intestine. Expressed at very low levels in brain, thymus, ovary, colon, fetal lung and fetal kidney. Expressed in muscle. Isoform 3 is expressed in pituitary gland. {ECO:0000269|PubMed:11854097, ECO:0000269|PubMed:23143598, ECO:0000269|PubMed:9521868}. |
IGSF1 CRISPR/Cas9 KO Plasmid (h) - sc-410833 from Santa Cruz Biotechnology
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IGSF1 HDR Plasmid (h) - sc-410833-HDR from Santa Cruz Biotechnology
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IGSF1 Double Nickase Plasmid (h) - sc-410833-NIC from Santa Cruz Biotechnology
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IGSF1 Double Nickase Plasmid (h2) - sc-410833-NIC-2 from Santa Cruz Biotechnology
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IGSF1 CRISPR Activation Plasmid (h) - sc-410833-ACT from Santa Cruz Biotechnology
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IGSF1 CRISPR Activation Plasmid (h2) - sc-410833-ACT-2 from Santa Cruz Biotechnology
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IGSF1 Lentiviral Activation Particles (h) - sc-410833-LAC from Santa Cruz Biotechnology
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IGSF1 Lentiviral Activation Particles (h2) - sc-410833-LAC-2 from Santa Cruz Biotechnology
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IGSF1 siRNA (h) - sc-91038 from Santa Cruz Biotechnology
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IGSF1 shRNA Plasmid (h) - sc-91038-SH from Santa Cruz Biotechnology
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IGSF1 shRNA (h) Lentiviral Particles - sc-91038-V from Santa Cruz Biotechnology
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IGSF1 RNAi - H00003547-R02 from Novus Biologicals
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IGSF1 RNAi - H00003547-R01 from Novus Biologicals
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MISSION® esiRNA - EHU077151 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10538 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10538 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR13068 from Sigma-Aldrich
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IGSF1 siRNA (Human) - CRH2367 from Cohesion Biosciences
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IGSF1 - MBS8219651 from MyBioSource
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shRNA set against Human Igsf1 (NM_001555.4) - SHH317789 from Creative biogene
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Human IGSF1 siRNA - orb262869 from Biorbyt
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IGSF1 shRNA Plasmid (Human) - CHH2367 from Cohesion Biosciences
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IGSF1 miRNA 3'UTR clone - MiUTR3H-02585 from Creative biogene
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IGSF1 miRNA 3'UTR clone - MiUTR3H-02586 from Creative biogene
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