| Gene Symbol |
HSP70.2
|
| Entrez Gene |
396648
|
| Alt Symbol |
HSPA1A, HSPA1B
|
| Species |
Pig
|
| Gene Type |
protein-coding
|
| Description |
heat shock protein 70.2
|
| Other Description |
heat shock 70 kDa protein 1B|heat shock 70 kDa protein 2|heat shock 70kDa protein 1A|heat shock 70kDa protein 1B
|
| Swissprots |
Q6S4N2
|
| Accessions |
CAC35386 CAN13333 CAN87708 Q6S4N2 AY466608 AAR30953 NM_213766 NP_998931
|
| Function |
In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation. {ECO:0000250|UniProtKB:P08107}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. {ECO:0000250}.
|
| Tissue Specificity |
Testis-specific.
|
| Top Pathways |
Protein processing in endoplasmic reticulum, Spliceosome, Toxoplasmosis, Endocytosis, Influenza A
|