| Gene Symbol |
Gcnt1
|
| Entrez Gene |
14537
|
| Alt Symbol |
5630400D21Rik, B130048E03, C2 GlcNAcT, C2GNT, IGnT
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
glucosaminyl (N-acetyl) transferase 1, core 2
|
| Other Description |
beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase|beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (Core 2 branching enzyme) (Core2-GlcNAc-transferase) (C2GNT)|core 2-branching enzyme|core2-GlcNAc-transferase
|
| Swissprots |
Q8BRB2 O35981 Q09324
|
| Accessions |
Q09324 AK017462 AK045216 BAC32265 AK167048 AK199888 BC039126 AAH39126 BP762673 BY010642 BY431975 BY768580 CJ092264 D87332 BAA22998 D87333 BAA22999 U19265 AAA60948 XM_006526679 XP_006526742 XM_011247144 XP_011245446 NM_001136484 NP_001129956 NM_010265 NP_034395 NM_173442 NP_775618
|
| Function |
Glycosyltransferase that catalyzes the transfer of an N- acetylglucosamine moiety onto mucin-type core 1 O-glycan to form the branched mucin-type core 2 O-glycan. Mucin-type core 2 O- glycans play an important role in leukocyte extravasation as they serve as scaffolds for the display of the selectin ligand sialyl Lewis X by leukocytes. {ECO:0000269|PubMed:7983056}.
|
| Subcellular Location |
Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Note=Also detected in the trans-Golgi network. {ECO:0000250}.
|
| Tissue Specificity |
Expressed in kidney, liver, stomach, spleen, lung and brain. {ECO:0000269|PubMed:9341170}.
|
| Top Pathways |
Mucin type O-Glycan biosynthesis
|