| Gene Symbol |
DCC
|
| Entrez Gene |
1630
|
| Alt Symbol |
CRC18, CRCR1, IGDCC1, MRMV1, NTN1R1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
DCC netrin 1 receptor
|
| Other Description |
colorectal cancer suppressor|colorectal tumor suppressor|deleted in colorectal cancer protein|deleted in colorectal carcinoma|immunoglobulin superfamily DCC subclass member 1|immunoglobulin superfamily, DCC subclass, member 1|netrin receptor DCC|tumor suppressor protein DCC
|
| Swissprots |
P43146
|
| Accessions |
AAA52174 AAA52175 AAA52176 AAA52177 AAA52178 AAA52179 AAA52180 AAA52181 AAB31484 EAW62991 EAW62992 EAW62993 EAW62994 P43146 AK302643 BAG63884 AK310385 AW949550 BC036524 AAH36524 BC152808 AAI52809 M32292 AAA35751 X76132 CAA53735 XM_011525843 XP_011524145 XM_011525844 XP_011524146 XM_011525845 XP_011524147 XM_011525846 XP_011524148 NM_005215 NP_005206
|
| Function |
Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene. {ECO:0000269|PubMed:8187090, ECO:0000269|PubMed:8861902}.
|
| Subcellular Location |
Membrane; Single-pass type I membrane protein.
|
| Tissue Specificity |
Found in axons of the central and peripheral nervous system and in differentiated cell types of the intestine. Not expressed in colorectal tumor cells that lost their capacity to differentiate into mucus producing cells. {ECO:0000269|PubMed:7926722}.
|
| Top Pathways |
Axon guidance, Colorectal cancer
|