DCC

Gene Symbol	DCC
Entrez Gene	1630
Alt Symbol	CRC18, CRCR1, IGDCC1, MRMV1, NTN1R1
Species	Human
Gene Type	protein-coding
Description	DCC netrin 1 receptor
Other Description	colorectal cancer suppressor|colorectal tumor suppressor|deleted in colorectal cancer protein|deleted in colorectal carcinoma|immunoglobulin superfamily DCC subclass member 1|immunoglobulin superfamily, DCC subclass, member 1|netrin receptor DCC|tumor suppressor protein DCC
Swissprots	P43146
Accessions	AAA52174 AAA52175 AAA52176 AAA52177 AAA52178 AAA52179 AAA52180 AAA52181 AAB31484 EAW62991 EAW62992 EAW62993 EAW62994 P43146 AK302643 BAG63884 AK310385 AW949550 BC036524 AAH36524 BC152808 AAI52809 M32292 AAA35751 X76132 CAA53735 XM_011525843 XP_011524145 XM_011525844 XP_011524146 XM_011525845 XP_011524147 XM_011525846 XP_011524148 NM_005215 NP_005206
Function	Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene. {ECO:0000269|PubMed:8187090, ECO:0000269|PubMed:8861902}.
Subcellular Location	Membrane; Single-pass type I membrane protein.
Tissue Specificity	Found in axons of the central and peripheral nervous system and in differentiated cell types of the intestine. Not expressed in colorectal tumor cells that lost their capacity to differentiate into mucus producing cells. {ECO:0000269|PubMed:7926722}.
Top Pathways	Axon guidance, Colorectal cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

DCC peptide - ab197596 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

DCC peptide - ab197972 from Abcam Category Peptide Prices $240.00 Sizes 1 mg

Human DCC protein fragment - ab157070 from Abcam Category Protein Source E. coli Species Human

DCC Antibody Blocking Peptide - LS-E1592 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DCC Antibody Blocking Peptide - LS-E6471 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DCC Antibody Blocking Peptide - LS-E16962 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DCC-Antibody-Center-Blocking-peptide - BP12334c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

DCC Blocking Peptide - 33R-7153 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

DCC Blocking Peptide - abx062092 from Abbexa Category Peptide Species Human, Mouse, Rat, Monkey

DCC-Specific fusion protein - ag16235 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human Deleted In Colorectal Carcinoma, GST-tagged - DCC-2110H from Creative Biomart Category Protein Source E. coli .

DCC Blocking Peptide - CBP3198 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Monkey

DCC (F465) Peptide - BS3232P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human Netrin receptor DCC(DCC) ,partial - CSB-YP006536HU CSB-EP006536HU CSB-BP006536HU CSB-MP006536HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human DCC Protein, CF - 8637-DC from R&D Systems Category Protein Prices $329.00 Sizes 50 µg Source Human embryonic kidney cell, HEK293-derived Phe32-Asn1097, with a C-terminal 6-His tag Species Human

Netrin receptor DCC - TP318506 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

DCC Recombinant Protein Antigen - NBP2-49606PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E. coli Species Human

DCC-Blocking-Peptide-C-term - BP21272b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

DCC Peptide, Human - M34GP04075H from Creative Peptides Category Peptide Source Synthetic. Species Human

DCC Recombinant Protein Antigen - NBP2-56793PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Netrin receptor DCC (DCC), partial, Recombinant Protein - MBS949084 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Recombinant Mouse DCC Fc Chimera Protein, CF - 844-DC from Novus Biologicals Category Protein Prices $329.00 Sizes 50 µg

Recombinant Human DCC Protein, CF - 8637-DC from Novus Biologicals Category Protein Prices $329.00 Sizes 50 µg Species Human

Recombinant Human DCC Protein, MYC/DDK-tagged - DCC-1171H from Creative Biomart Category Protein Source HEK293 Species Human

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