| Gene Symbol |
ZMYND11
|
| Entrez Gene |
10771
|
| Alt Symbol |
BRAM1, BS69, MRD30
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
zinc finger, MYND-type containing 11
|
| Other Description |
adenovirus 5 E1A-binding protein|bone morphogenetic protein receptor-associated molecule 1|zinc finger MYND domain-containing protein 11
|
| Swissprots |
Q2LD47 Q15326 Q8N4B3 Q2LD48 Q5VUI1 B7Z293 B2R6G8 Q2LD45 F6UH50 Q2LD46
|
| Accessions |
EAW86539 EAW86540 EAW86541 EAW86542 Q15326 AI031881 AI244299 AK294469 BAH11779 AK294781 BAH11882 AK296427 BAH12348 AK296518 BAH12377 AK312570 BAG35465 AY732489 AAV33128 BC012586 AAH12586 BC034784 AAH34784 BC091489 AAH91489 BP873033 BU680177 CB241408 CF137216 DB236591 DB521520 DC376390 DQ335452 ABC72408 DQ335453 ABC72409 DQ335454 ABC72410 DQ335455 ABC72411 DQ891317 ABM82243 DQ894501 ABM85427 X86098 CAA60052 XM_005252359 XP_005252416 XM_005252360 XP_005252417 XM_005252361 XP_005252418 XM_005252362 XP_005252419 XM_006717376 XP_006717439 XM_011519301 XP_011517603 XM_011519302 XP_011517604 NM_001202464 NP_001189393 NM_001202465 NP_001189394 NM_001202466 NP_001189395 NM_001202467 NP_001189396 NM_001202468 NP_001189397 NM_006624 NP_006615 NM_212479 NP_997644
|
| Function |
Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2) (By similarity). Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage. Acts as a tumor-suppressor by repressing a transcriptional program essential for tumor cell growth. {ECO:0000250|UniProtKB:Q8R5C8, ECO:0000269|PubMed:10734313, ECO:0000269|PubMed:16565076}.
|
| Subcellular Location |
Nucleus. Chromosome. Note=Associates with chromatin and mitotic chromosomes.
|
| Tissue Specificity |
Ubiquitous. {ECO:0000269|PubMed:16565076}.
|
