| Gene Symbol | DYNC1LI1 |
|---|---|
| Entrez Gene | 51143 |
| Alt Symbol | DNCLI1, LIC1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | dynein, cytoplasmic 1, light intermediate chain 1 |
| Other Description | DLC-A|cytoplasmic dynein 1 light intermediate chain 1|dynein light chain A|dynein light chain-A|dynein light intermediate chain 1, cytosolic|dynein, cytoplasmic, light intermediate polypeptide 1 |
| Swissprots | Q53HK7 Q9Y6G9 Q53HC8 A2RRG7 |
| Accessions | EAW64431 EAW64432 EAW64433 Q9Y6G9 AF078849 AAD44481 AK001081 BAG50854 AK074348 AK222573 BAD96293 AK222653 BAD96373 AK293253 BAG56785 BC131620 AAI31621 BU521223 BX649189 CAE46207 DA284201 NM_016141 NP_057225 |
| Function | Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress throuh the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores. {ECO:0000269|PubMed:19229290}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:19229290}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:19229290}. |
| Top Pathways | Vasopressin-regulated water reabsorption, Phagosome, Salmonella infection |