Casp8

Gene Symbol Casp8
Entrez Gene 12370
Alt Symbol CASP-8, FLICE, MACH, Mch5
Species Mouse
Gene Type protein-coding
Description caspase 8
Other Description Fas-linked ICE-like protease|caspase-8
Swissprots O89110 O35669
Accessions AAC40132 AAW80309 EDL00099 EDL00100 O89110 AF067834 AAC40131 AJ000641 CAA04196 AJ007749 CAA07677 AK146758 BAE27412 AK153340 BAE31918 AK156135 AK168812 BAE40639 AK185575 AK189229 BC006737 AAH06737 BC049955 AAH49955 BY203369 CT010166 CAJ18374 XM_006495634 XP_006495697 NM_001080126 NP_001073595 NM_001277926 NP_001264855 NM_009812 NP_033942
Function Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death- inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein.
Subcellular Location Cytoplasm.
Tissue Specificity Expressed in a wide variety of tissues. Highest expression in spleen, thymus, lung, liver and kidney. Lower expression in heart, brain, testis and skeletal muscle.
Top Pathways Chagas disease (American trypanosomiasis), Viral carcinogenesis, TNF signaling pathway, Legionellosis, Non-alcoholic fatty liver disease (NAFLD)

Cleaved Caspase-8 (Asp387) (D5B2) XP ® Rabbit mAb (Mouse Specific) (PE Conjugate) - 14071 from Cell Signaling Technology

Prices $329.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Polyclonal
Flow cytometric analysis of Raw 264.7 cells, untreated (blue) or treated with Cycloheximide #2112 (10 μg/ml, overnight) and mTNF-α #5178 (20 ng/ml, 4 hr; green), using Cleaved Caspase-8 (Asp387) (D5B2) XP ® Rabbit mAb (Mouse Specific) (PE Conjugate).

Caspase-8 Antibody (Mouse Specific) - 4927 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from BaF3, Raw264.7 and C2C12 cell lines, using Caspase-8 Antibody (Mouse Specific).

Cleaved Caspase-8 (Asp387) (D5B2) XP ® Rabbit mAb (Mouse Specific) - 8592 from Cell Signaling Technology

Prices $119.00, $318.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D5B2
Western blot analysis of extracts from 293T cells, mock transfected (-) or transfected with a construct overexpressing mouse caspase-8 (mCasp8) (+), using Cleaved Caspase-8 (Asp387) (D5B2) XP ® Rabbit mAb (Mouse Specific).

Cleaved Caspase-8 (Asp387) Antibody (Mouse Specific) - 9429 from Cell Signaling Technology

Prices $109.00, $287.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from COS cells, mock transfected (-) or transfected with a construct overexpressing mouse caspase-8 (+), using Cleaved Caspase-8 (Asp387) Antibody (Mouse Specific).

Anti-Caspase-8 antibody - ab138485 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Caspase-8 antibody (ab138485) at 1 µg/ml (Milk blocking 3%)Lane 1 : Spleen (Mouse) Tissue LysateLane 2 : Thymus (Mouse) Tissue LysateLane 3 : Lung (Mouse) Whole Cell Lysate - normal tissueLane 4 : Liver (Mouse) Tissue LysateLane 5 : RAW 264.7 (Mouse leukaemic monocyte macrophage cell line) Whole Cell LysateLysates/proteins at 25 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) (ab97051) at 1/10000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Caspase-8 Antibody - NBP1-05123 from Novus Biologicals

Prices $129.00, $199.00
Sizes 25 µl, 50 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: Caspase-8 Antibody [NBP1-05123] - Formalin-fixed, paraffin-embedded sections from a brain tumor tissue array stained for Caspase-8 expression using NBP1-05123 at 1:2000. A. Anaplastic glioma cores from two different patients, positive (left) and negative (right) staining for caspase-8. B. Higher magnification from the caspase-8 positive (A, left) core.

Caspase-8 Antibody (C502S) - NBP1-45445 from Novus Biologicals

Prices $365.00
Sizes 100 µg
Host Rabbit
Clonality Monoclonal
Clone C502S

Caspase 8 Polyclonal Antibody - bs-0052R from Bioss

Prices $279.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
L1 mouse liver lysates L2 mouse spleen lysates probed with Anti Caspase 8 Polyclonal Antibody, Unconjugated (bs-0052R) at 1:200 overnight at 4˚C. Followed by conjugation to secondary antibody (bs-0295G-HRP) at 1:3000 for 90 min at 37˚C. Predicted band 12kD. Observed band size:48kD.\\n

Caspase 8 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-0052R-A350 from Bioss

Prices $379.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Caspase 8 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-0052R-A488 from Bioss

Prices $379.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Caspase 8 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-0052R-A555 from Bioss

Prices $379.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Caspase 8 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-0052R-A647 from Bioss

Prices $379.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Caspase 8 Polyclonal Antibody, Cy3 Conjugated - bs-0052R-Cy3 from Bioss

Prices $379.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Caspase 8 Polyclonal Antibody, Cy5 Conjugated - bs-0052R-Cy5 from Bioss

Prices $379.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Caspase 8 Polyclonal Antibody, Cy5.5 Conjugated - bs-0052R-Cy5.5 from Bioss

Prices $379.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Caspase 8 Polyclonal Antibody, Cy7 Conjugated - bs-0052R-Cy7 from Bioss

Prices $379.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Caspase 8 Polyclonal Antibody, FITC Conjugated - bs-0052R-FITC from Bioss

Prices $379.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Caspase 8 Polyclonal Antibody, Biotin Conjugated - bs-0052R-Biotin from Bioss

Prices $359.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Caspase 8 Polyclonal Antibody, HRP Conjugated - bs-0052R-HRP from Bioss

Prices $379.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Caspase 8 (active) antibody - GTX59607 from GeneTex

Prices $319.00
Sizes 100 μg
Host Rabbit
Clonality Polyclonal
Anti-Caspase 8 (active) antibody used in Western blot. GTX59607

CASP8 Antibody (OABF00025) - OABF00025 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Caspase 8 antibody - 70R-30657 from Fitzgerald

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

CEB alpha antibody (Ser21) - 70R-30650 from Fitzgerald

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

CEBP alpha antibody (Thr226) - 70R-33444 from Fitzgerald

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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