| Gene Symbol |
Casp8
|
| Entrez Gene |
12370
|
| Alt Symbol |
CASP-8, FLICE, MACH, Mch5
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
caspase 8
|
| Other Description |
Fas-linked ICE-like protease|caspase-8
|
| Swissprots |
O89110 O35669
|
| Accessions |
AAC40132 AAW80309 EDL00099 EDL00100 O89110 AF067834 AAC40131 AJ000641 CAA04196 AJ007749 CAA07677 AK146758 BAE27412 AK153340 BAE31918 AK156135 AK168812 BAE40639 AK185575 AK189229 BC006737 AAH06737 BC049955 AAH49955 BY203369 CT010166 CAJ18374 XM_006495634 XP_006495697 NM_001080126 NP_001073595 NM_001277926 NP_001264855 NM_009812 NP_033942
|
| Function |
Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death- inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein.
|
| Subcellular Location |
Cytoplasm.
|
| Tissue Specificity |
Expressed in a wide variety of tissues. Highest expression in spleen, thymus, lung, liver and kidney. Lower expression in heart, brain, testis and skeletal muscle.
|
| Top Pathways |
Chagas disease (American trypanosomiasis), Viral carcinogenesis, TNF signaling pathway, Legionellosis, Non-alcoholic fatty liver disease (NAFLD)
|