FANCI

Gene Symbol FANCI
Entrez Gene 55215
Alt Symbol KIAA1794
Species Human
Gene Type protein-coding
Description Fanconi anemia, complementation group I
Other Description Fanconi anemia group I protein
Swissprots Q96ST0 Q9NVI1 Q9BT96 A6NJZ0 Q96JN1 A4ZVE4 A5YMH4
Accessions EAX02039 EAX02040 EAX02041 EAX02042 EAX02043 EAX02044 Q9NVI1 AB058697 BAB47423 AK001581 BAA91770 AK027564 BAB55200 AK055176 BAG51480 BC004277 AAH04277 BC021859 BC140769 AAI40770 BC144483 AAI44484 BC146804 BC166621 AAI66621 BM461935 BQ050477 BU187299 CN365698 EF469766 ABP88002 EF567077 ABQ63084 XM_011521756 XP_011520058 XM_011521757 XP_011520059 XM_011521758 XP_011520060 XM_011521759 XP_011520061 XM_011521760 XP_011520062 XM_011521761 XP_011520063 XM_011521762 XP_011520064 XM_011521763 XP_011520065 XM_011521764 XP_011520066 XM_011521765 XP_011520067 XM_011521766 XP_011520068 XM_011521767 XP_011520069 XM_011521768 XP_011520070 XM_011521769 XP_011520071 NM_001113378 NP_001106849 NM_018193 NP_060663
Function Plays an essential role in the repair of DNA double- strand breaks by homologous recombination and in the repair of interstrand DNA cross-links (ICLs) by promoting FANCD2 monoubiquitination by FANCL and participating in recruitment to DNA repair sites. Required for maintenance of chromosomal stability. Specifically binds branched DNA: binds both single- stranded DNA (ssDNA) and double-stranded DNA (dsDNA). Participates in S phase and G2 phase checkpoint activation upon DNA damage. {ECO:0000269|PubMed:17412408, ECO:0000269|PubMed:17452773, ECO:0000269|PubMed:17460694, ECO:0000269|PubMed:19111657}.
Subcellular Location Nucleus {ECO:0000269|PubMed:17412408, ECO:0000269|PubMed:17460694, ECO:0000269|PubMed:19465922}. Note=Observed in spots localized in pairs on the sister chromatids of mitotic chromosome arms and not centromeres, one on each chromatids. These foci coincide with common fragile sites. They are frequently interlinked through BLM-associated ultra-fine DNA bridges.
Top Pathways Fanconi anemia pathway

Human FANCI protein fragment - ab132153 from Abcam

Category Protein
Source Wheat germ
Species Human
SDS-PAGE analysis of ab132153 on a 12.5% gel stained with Coomassie Blue.

Recombinant Human FANCI Protein - H00055215-P01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

FANCI - H00055215-P01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Source in vitro transl.
Species Human

FANCI - H00055215-P01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Source in vitro transl.
Species Human

FANCI fusion protein - Ag14386 from Proteintech Group

Category Protein
Prices $199.00
Sizes 50 μg
Source E. coli -derived, PGEX-4T
Species Human

FANCI fusion protein - Ag15153 from Proteintech Group

Category Protein
Prices $199.00
Sizes 50 μg
Source E. coli -derived, PET28a
Species Human

Recombinant Human FANCI, GST-tagged - FANCI-12740H from Creative Biomart

Category Protein
Source E.coli
Species Human

Recombinant Human Fanconi anemia group I protein(FANCI) ,partial - CSB-YP889120HU CSB-EP889120HU CSB-BP889120HU CSB-MP889120HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

FANCI Recombinant Protein Antigen - NBP1-84608PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

FANCI Peptide, Human - M34GP05527H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

Fanconi anemia group I protein (FANCI), partial, Recombinant Protein - MBS1399970 from MyBioSource

Category Protein
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human

FANCI Recombinant Protein Antigen - NBP2-55040PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human
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