AKR7A2

Gene Symbol AKR7A2
Entrez Gene 8574
Alt Symbol AFAR, AFAR1, AFB1-AR1, AKR7
Species Human
Gene Type protein-coding
Description aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
Other Description AFB1 aldehyde reductase 1|AFB1-AR 1|HEL-S-166mP|SSA reductase|aflatoxin B1 aldehyde reductase member 2|aflatoxin beta1 aldehyde reductase|aldoketoreductase 7|epididymis secretory sperm binding protein Li 166mP|succinic semialdehyde reductase
Swissprots O75749 Q5TG63 O43488
Accessions EAW94881 O43488 AA037839 AF026947 AAC52104 AK225267 AK303131 BAG64236 AK310609 BC004111 AAH04111 BC007352 AAH07352 BC010852 AAH10852 BC011586 AAH11586 BC012171 AAH12171 BC013996 AAH13996 BG385885 BK000395 DAA00088 BM551906 BT007347 AAP36011 BU944847 DQ891003 ABM81929 DQ894182 ABM85108 EU794591 ACJ13645 Y16675 CAA76347 XR_946785 NM_003689 NP_003680
Function Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2- nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen. {ECO:0000269|PubMed:17591773, ECO:0000269|PubMed:9576847}.
Subcellular Location Golgi apparatus {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:9576847}.
Tissue Specificity Detected in brain, liver, small intestine and testis, and at lower levels in heart, prostate, skeletal muscle and spleen. Detected in kidney proximal and distal tubules, endothelial cells lining the Bowman's capsules and some cysts. Detected at low levels in lung and pancreas (at protein level). Widely expressed. {ECO:0000269|PubMed:10510318, ECO:0000269|PubMed:9576847}.
Top Pathways Metabolism of xenobiotics by cytochrome P450

AKR7A (C-19) - sc-27766 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
AKR7A (C-19): sc-27766. Western blot analysis of AKR7A3 expression in non-transfected 293T: sc-117752 (A), human AKR7A3 transfected 293T: sc-114340 (B) and Hep G2 (C) whole cell lysates.

AKR7A (E-11) - sc-365400 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
AKR7A (E-11): sc-365400. Western blot analysis of AKR7A2 expression in non-transfected: sc-110760 (A) and human AKR7A2 transfected: sc-111315 (B) 293 whole cell lysates.

AKR7A (E-9) - sc-137187 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
AKR7 (E-9): sc-137187. Western blot analysis of AKR7A3 expression in non-transfected 293T: sc-117752 (A), human AKR7A3 transfected 293T: sc-114111 (B), Hep G2 (C) and HL-60 (D) whole cell lysates.

AKR7A (F-8) - sc-137186 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
AKR7 (F-8): sc-137186. Western blot analysis of AKR7A3 expression in non-transfected 293T: sc-117752 (A), human AKR7A3 transfected 293T: sc-114111 (B), Hep G2 (C) and HL-60 (D) whole cell lysates.

AKR7A (H-300) - sc-32944 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
AKR7A (H-300): sc-32944. Western blot analysis of AKR7A3 expression in non-transfected 293T: sc-117752 (A), human AKR7A3 transfected 293T: sc-114340 (B) and Hep G2 (C) whole cell lysates.

AKR7A (L-18) - sc-27765 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
AKR7A (L-18): sc-27765. Western blot analysis of AKR7A expression in non-transfected: sc-117752 (A) and mouse AKR7A transfected: sc-124941 (B) 293T whole cell lysates.

AKR7A2 (Y02) - sc-100503 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
AKR7A2 (Y02): sc-100503. Western blot analysis of AKR7A2 expression in HL-60 whole cell lysate.

Anti-AKR7A2 antibody - ab175295 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human liver cancer tissue labelling AKR7A2 with ab175295 at 1/200. Magnification: 200x.

Anti-AKR7A2 antibody - ab82397 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-AKR7A2 antibody (ab82397) at 1/50 dilution + Mouse liver tissue lysates at 12.5 µg

Anti-AKR7A2 antibody - ab56442 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-AKR7A2 / AFAR Antibody - LS-C306188 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-AKR7A2 / AFAR Antibody - LS-C309394 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-AKR7A2 / AFAR Antibody - LS-C309395 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-AKR7A2 / AFAR Antibody (N-Terminus) - LS-C347631 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-AKR7A2 / AFAR Antibody - LS-C306186 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-AKR7A2 / AFAR Antibody (N-Terminus) - LS-C345648 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of ARK72 Antibody with human Fetal Lung lysate.

Anti-AKR7A2 / AFAR Antibody (aa82-131) - LS-C151875 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
AKR7A2 / AFAR antibody Western Blot of Human Liver.

Anti-AKR7A2 / AFAR Antibody (aa101-129) - LS-C99074 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of anti-AKR7A2 antibody in 293 cell line lysates (35 ug/lane). AKR7A2 (arrow) was detected using the purified antibody. Western blot of anti-AKR7A2 Antibody in mouse liver tissue lysates (35 ug/lane). AKR7A2 (arrow) was detected using the purified antibody.

Anti-AKR7A2 / AFAR Antibody - LS-C137240 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-AKR7A2 / AFAR Antibody (aa84-359) - LS-C185612 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
AKR7A2 antibody detects AKR7A2 protein at cytosol on SkHep1 xenograft by immunohistochemical analysis. Sample: Paraffin-embedded SkHep2 xenograft. AKR7A2 antibody dilution:1:500.

Anti-AKR7A2 / AFAR Antibody - LS-C331369 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded human kidney cancer using AKR7A2 antibody at dilution of 1:200 (400x lens).

Anti-AKR7A2 / AFAR Antibody - LS-C192489 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of AKR7A2 pAb in extracts from HepG2 cells.

AKR7A2 Antibody - NBP1-32828 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: AKR7A2 Antibody [NBP1-32828] - Sample (30 ug of whole cell lysate) A: A431 10% SDS PAGE; antibody diluted at 1:1000.

AKR7A2 Antibody (2A6) - H00008574-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2A6
Western Blot: AKR7A2 Antibody (2A6) [H00008574-M01] - AKR7A2 monoclonal antibody (M01), clone 2A6 Analysis of AKR7A2 expression in HL-60.

AKR7A2 Antibody - H00008574-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Search more