AKR7A2

Gene Symbol	AKR7A2
Entrez Gene	8574
Alt Symbol	AFAR, AFAR1, AFB1-AR1, AKR7
Species	Human
Gene Type	protein-coding
Description	aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
Other Description	AFB1 aldehyde reductase 1|AFB1-AR 1|HEL-S-166mP|SSA reductase|aflatoxin B1 aldehyde reductase member 2|aflatoxin beta1 aldehyde reductase|aldoketoreductase 7|epididymis secretory sperm binding protein Li 166mP|succinic semialdehyde reductase
Swissprots	O75749 Q5TG63 O43488
Accessions	EAW94881 O43488 AA037839 AF026947 AAC52104 AK225267 AK303131 BAG64236 AK310609 BC004111 AAH04111 BC007352 AAH07352 BC010852 AAH10852 BC011586 AAH11586 BC012171 AAH12171 BC013996 AAH13996 BG385885 BK000395 DAA00088 BM551906 BT007347 AAP36011 BU944847 DQ891003 ABM81929 DQ894182 ABM85108 EU794591 ACJ13645 Y16675 CAA76347 XR_946785 NM_003689 NP_003680
Function	Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2- nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen. {ECO:0000269|PubMed:17591773, ECO:0000269|PubMed:9576847}.
Subcellular Location	Golgi apparatus {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:9576847}.
Tissue Specificity	Detected in brain, liver, small intestine and testis, and at lower levels in heart, prostate, skeletal muscle and spleen. Detected in kidney proximal and distal tubules, endothelial cells lining the Bowman's capsules and some cysts. Detected at low levels in lung and pancreas (at protein level). Widely expressed. {ECO:0000269|PubMed:10510318, ECO:0000269|PubMed:9576847}.
Top Pathways	Metabolism of xenobiotics by cytochrome P450

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human AKR7A2 full length protein - ab168001 from Abcam Category Protein Prices $465.00 Sizes 100 µg Source E. coli Species Human

Human AKR7A2 full length protein - ab93634 from Abcam Category Protein Prices $188.00 Sizes 50 µg Source E. coli Species Human

AKR7A2 / AFAR Antibody Blocking Peptide - LS-E23692 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

AKR7A2 / AFAR Antibody Blocking Peptide - LS-E8747 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

AKR7A2 Recombinant Protein - H00008574-P02 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

AKR7A2 Recombinant Protein - H00008574-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human AKR7A2 Protein - P3498 from Novus Biologicals Category Protein Prices $669.00 Sizes 100 µg Source E. coli Species Human

AKR7A2-Antibody-N-term-Blocking-Peptide - BP7186a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

AKR7A2 Protein (OPPA01826) - OPPA01826 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Human Aldo-Keto Reductase Family Member A2 protein - orb90024 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E.coli

AKR7A2 protein (His tag) - 80R-1255 from Fitzgerald Category Protein Prices $340.00 Sizes 100 µg Source E.coli

AKR7A2 (1-359, His-tag) - AR09377PU-L from Acris Antibodies Category Protein Prices $1,020.00 Sizes 500 µg Source E. coli Species Human

AKR7A2 (1-359, His-tag) - AR09377PU-N from Acris Antibodies Category Protein Prices $420.00 Sizes 100 µg Source E. coli Species Human

AKR7A2 - H00008574-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

AKR7A2 - H00008574-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

AKR7A2 - H00008574-P02 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

AKR7A2 - H00008574-P02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

AKR7A2 - H00008574-P02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

AKR7A2 - P3498 from Acris Antibodies Category Protein Prices $580.00 Sizes 100 µg Species Human

AKR7A2, 1-359aa, Human, His tag, E. coli - 01-1780-A2 from ARP American Research Products Category Protein Prices $189.00, $449.00, $1,089.00 Sizes 20 µg, 50 µg, 500 µg Species Human

AKR7A2 fusion protein - Ag1049 from Proteintech Group Category Protein Source E. coli -derived, PGEX-4T Species Human

AKR7A2 Human - ENPS-492 from NeoScientific Category Protein Prices $65.00, $169.00, $4,680.00 Sizes 5 µg, 20 µg, 1 mg Source Escherichia Coli. Species Human

Recombinant Human AKR7A2 - BP000863-ENZ-485 from Syd Labs Category Protein Prices $160.00, $3,600.00 Sizes 20 µg, 1 mg Source E. coli-derived. Species Human

AKR7A2, 1-359aa, Recombinant Protein - GWB-P1560M from Genway Biotech Category Protein Prices $400.00, $1,200.00 Sizes 100 μg, 500 μg Source E.coli Species Human

Recombinant Human AKR7A2, His-tagged - AKR7A2-26147TH from Creative Biomart Category Protein Source E. coli

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