| Gene Symbol |
thraa
|
| Entrez Gene |
30670
|
| Alt Symbol |
TR[a]1, nr1a1, thra, thral, tra, tra1, wu:fb59g07
|
| Species |
Zebrafish
|
| Gene Type |
protein-coding
|
| Description |
thyroid hormone receptor alpha a
|
| Other Description |
NR1A1-A|TRalpha-1|c-erbA|nuclear receptor subfamily 1 group A member 1-A|thyroid hormone receptor alpha 1|thyroid hormone receptor alpha-1|thyroid hormone receptor alpha-A|zTRalpha-A
|
| Swissprots |
Q4V9Q5 Q98867 A0ST47
|
| Accessions |
AAB68762 AAB68763 Q98867 BC096778 AAH96778 BC164729 AAI64729 DQ991961 ABK64188 U54796 AAA99811 XM_005163985 XP_005164042 XM_005163986 XP_005164043 XM_009299514 XP_009297789 XM_009299515 XP_009297790 XM_009299516 XP_009297791 NM_131396 NP_571471
|
| Function |
High affinity receptor for triiodothyronine (By similarity). In the absence of thyroid hormone during late blastula stage development, acts as a transcriptional repressor. Whereas in the presence of thyroid hormone, can act as an activator of transcription. In addition, represses retinoic acid (RA)-signaling during blastula and gastrula stages of development. {ECO:0000250, ECO:0000269|PubMed:17583703, ECO:0000269|PubMed:9447705}.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407, ECO:0000269|PubMed:9447705}.
|
| Tissue Specificity |
After the mid-blastula transition (MBT), expressed throughout the deep cells, which give rise to the embryo proper. In adults, isoform 2 shows highest expression in the eye and liver. Expressed in adult gonads. {ECO:0000269|PubMed:9447705}.
|
| Top Pathways |
Neuroactive ligand-receptor interaction
|