NAE1

Gene Symbol	NAE1
Entrez Gene	8883
Alt Symbol	A-116A10.1, APPBP1, HPP1, ula-1
Species	Human
Gene Type	protein-coding
Description	NEDD8 activating enzyme E1 subunit 1
Other Description	APP-BP1|NEDD8-activating enzyme E1 regulatory subunit|NEDD8-activating enzyme E1 subunit|amyloid beta precursor protein binding protein 1, 59kDa|amyloid beta precursor protein-binding protein 1, 59 kDa|amyloid beta precursor protein-binding protein 1, 59kD|amyloid protein-binding protein 1|proto-oncogene protein 1|protooncogene protein 1
Swissprots	B3KUP9 A6NFN4 Q13564 B2R700 A8MU28 A6NCK0
Accessions	AAC23784 CCQ43241 CDM22116 EAW83042 EAW83043 Q13564 AK097680 BAG53511 AK298159 BAH12735 AK307677 AK312784 BAG35647 AL136798 CAB66732 AY197612 AAP35030 BC000480 AAH00480 BC013301 AAH13301 BC041323 BM045535 BM785899 DQ892741 ABM83667 DQ895987 ABM86913 U50939 AAC50477 XM_005256215 XP_005256272 XM_011523422 XP_011521724 XM_011523423 XP_011521725 NM_001018159 NP_001018169 NM_001018160 NP_001018170 NM_001286500 NP_001273429 NM_003905 NP_003896
Function	Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation. {ECO:0000269|PubMed:10207026, ECO:0000269|PubMed:10722740, ECO:0000269|PubMed:12740388}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:14557245}. Note=Colocalizes with APP in lipid rafts.
Tissue Specificity	Ubiquitous in fetal tissues. Expressed throughout the adult brain. {ECO:0000269|PubMed:8626687}.
Top Pathways	Alzheimer's disease

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human APPBP1 full length protein - ab116199 from Abcam Category Protein Prices $402.00 Sizes 50 µg Source E. coli Species Human

NAE1 / APPBP1 Antibody Blocking Peptide - LS-E2157 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NAE1 / APPBP1 Antibody Blocking Peptide - LS-E8822 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NAE1 / APPBP1 Antibody Blocking Peptide - LS-E8823 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NAE1 / APPBP1 Antibody Blocking Peptide - LS-E21720 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NEDD8 Activating Enzyme (APPBP1/UBA3) Recombinant Protein - H00008883-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human NEDD8 Activating Enzyme (APPBP1/UBA3) Protein - NBP1-78854 from Novus Biologicals Category Protein Prices $349.00 Sizes 50 µg Source E. coli Species Human

NEDD8 Activating Enzyme (APPBP1/UBA3) Peptide - P2454 from Novus Biologicals Category Peptide Species Human

NEDD8 Activating Enzyme (APPBP1/UBA3) Peptide - P2452 from Novus Biologicals Category Peptide Species Human

NAE1-Antibody-Center-Blocking-peptide - BP13067c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

NAE1-APPBP1-Antibody-C-term-Blocking-peptide - BP7273e from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

NAE1-APPBP1-Antibody-C-term-Blocking-peptide - BP7273b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human NEDD8 E1 (APPBP1/UBA3), CF - E-313-025 from R&D Systems Category Protein Source E. coli-derived,

Recombinant Human GST-NEDD8 E1 (APPBP1/UBA3), CF - E-312-050 from R&D Systems Category Protein Source E. coli-derived, Contains an N-terminal GST (glutathione S-transferase) tag

Human NAE1 protein - orb168885 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Species Human

APPBP1 (1-534, His-tag) - AR50180PU-N from Acris Antibodies Category Protein Prices $1,010.00 Sizes 250 µg Source E. coli Species Human

APPBP1 (1-534, His-tag) - AR50180PU-S from Acris Antibodies Category Protein Prices $410.00 Sizes 50 µg Source E. coli Species Human

APPBP1 - H00008883-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

APPBP1 - H00008883-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

NEDD8 Activating Enzyme E1 Subunit 1, Human Recombinant - 228-12378-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Species Human

Recombinant Human NEDD8 Activating Enzyme E1 Subunit 1 - 228-12378-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Escherichia Coli. Species Human

Recombinant Human NEDD8 Activating Enzyme E1 Subunit 1 - 228-12378-3 from RayBiotech Category Protein Source Escherichia Coli. Species Human

NAE1, 1-534aa, Human, His tag, E.coli - 01-P1355 from ARP American Research Products Category Protein Prices $179.00, $449.00, $1,089.00 Sizes 10 µg, 50 µg, 250 µg Species Human

NAE1 fusion protein - ag6672 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

NAE1 fusion protein - ag7126 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

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