Gene Symbol | GRAP2 |
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Entrez Gene | 9402 |
Alt Symbol | GADS, GRAP-2, GRB2L, GRBLG, GRID, GRPL, GrbX, Grf40, Mona, P38 |
Species | Human |
Gene Type | protein-coding |
Description | GRB2-related adaptor protein 2 |
Other Description | GRB-2-like protein|GRB2-related adapter protein 2|GRB2-related protein with insert domain|SH3-SH2-SH3 adapter Mona|SH3-SH2-SH3 adaptor molecule|adapter protein GRID|grf-40|grf40 adapter protein|growth factor receptor-binding protein|growth factor receptor-bound protein 2-related adaptor protein 2|hematopoietic cell-associated adapter protein GrpL|hematopoietic cell-associated adaptor protein GRPL |
Swissprots | O75791 Q9NRB7 O43726 B7Z8I3 |
Accessions | EAW60356 EAW60357 EAW60358 EAW60359 EAW60360 EAW60361 O75791 AF042380 AAC69273 AF090456 AAD13027 AF102694 AAD04926 AF121002 AAF31758 AF129476 AAD41782 AF236119 AAF60319 AF236120 AAF60320 AJ011736 CAA09757 AK303280 BAH13929 AK303332 BAH13944 AK303470 BAH13969 AK303512 BAH13978 AK303657 BAH14008 AK312830 BAG35685 AY069959 AAL58573 BC025692 AAH25692 BC026002 AAH26002 CR456498 CAG30384 CR536524 CAG38761 CR541849 CAG46647 CU013095 CAK54526 CU013383 CAK54825 DC409651 DQ893144 ABM84070 DQ896431 ABM87430 HY091328 Y18051 CAA77021 XM_006724376 XP_006724439 XM_011530515 XP_011528817 XM_011530516 XP_011528818 NM_001291824 NP_001278753 NM_001291825 NP_001278754 NM_001291826 NP_001278755 NM_001291828 NP_001278757 NM_004810 NP_004801 |
Function | Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:21179510}. Cytoplasm {ECO:0000269|PubMed:21179510}. Endosome {ECO:0000269|PubMed:21179510}. |
Top Pathways | T cell receptor signaling pathway |
Gads CRISPR/Cas9 KO Plasmid (h) - sc-402831 from Santa Cruz Biotechnology
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Gads HDR Plasmid (h) - sc-402831-HDR from Santa Cruz Biotechnology
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Gads Double Nickase Plasmid (h) - sc-402831-NIC from Santa Cruz Biotechnology
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Gads Double Nickase Plasmid (h2) - sc-402831-NIC-2 from Santa Cruz Biotechnology
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Gads CRISPR Activation Plasmid (h) - sc-402831-ACT from Santa Cruz Biotechnology
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Gads CRISPR Activation Plasmid (h2) - sc-402831-ACT-2 from Santa Cruz Biotechnology
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Gads Lentiviral Activation Particles (h) - sc-402831-LAC from Santa Cruz Biotechnology
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Gads Lentiviral Activation Particles (h2) - sc-402831-LAC-2 from Santa Cruz Biotechnology
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Gads siRNA (h) - sc-40958 from Santa Cruz Biotechnology
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Gads shRNA Plasmid (h) - sc-40958-SH from Santa Cruz Biotechnology
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Gads shRNA (h) Lentiviral Particles - sc-40958-V from Santa Cruz Biotechnology
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GRAP2 RNAi - H00009402-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN9660 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9660 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01914 from Sigma-Aldrich
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GRAP2 siRNA (Human) - CRH6232 from Cohesion Biosciences
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GRAP2 - MBS8209626 from MyBioSource
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shRNA set against Human GRAP2 (NM_004810.2) - SHH307538 from Creative biogene
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shRNA set against Human GRAP2(NM_004810.2) - SHH103043 from Creative biogene
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Human GRAP2 siRNA - orb266734 from Biorbyt
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GRAP2 shRNA Plasmid (Human) - CHH6232 from Cohesion Biosciences
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GRAP2 miRNA 3'UTR clone - MiUTR1H-04249 from Creative biogene
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