| Gene Symbol |
PRKAB2
|
| Entrez Gene |
5565
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein kinase, AMP-activated, beta 2 non-catalytic subunit
|
| Other Description |
5'-AMP-activated protein kinase subunit beta-2|5'-AMP-activated protein kinase, beta-2 subunit|AMP-activated protein kinase beta 2 non-catalytic subunit|AMPK beta 2|AMPK beta-2 chain|AMPK subunit beta-2
|
| Swissprots |
A8K9V5 B4DH06 Q5VXY0 O43741
|
| Accessions |
AAM74153 CAH72644 EAW50945 O43741 AI026131 AI638769 AJ224538 CAA12030 AK023717 AK292820 BAF85509 AK294863 BAG57967 AK304069 BAG64976 AK310982 AK316005 BAH14376 AK316183 BAH14554 AL037763 AU118301 AV646012 AV660341 BC053610 AAH53610 BM563523 BM724633 BM769516 BU166852 BU619639 BX478507 CA311731 CB111633 DA698245 HQ257946 ADR82700 KJ534919 AHW56559 KJ535024 AHW56663 KJ535025 AHW56664 XM_011509728 XP_011508030 XM_011509729 XP_011508031 NM_005399 NP_005390 NR_103870 NR_103871
|
| Function |
Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).
|
| Top Pathways |
Non-alcoholic fatty liver disease (NAFLD), Glucagon signaling pathway, AMPK signaling pathway, Oxytocin signaling pathway, Circadian rhythm
|