CASP1

Gene Symbol	CASP1
Entrez Gene	834
Alt Symbol	ICE, IL1BC, P45
Species	Human
Gene Type	protein-coding
Description	caspase 1, apoptosis-related cysteine peptidase
Other Description	CASP1 nirs variant 1|IL-1 beta-converting enzyme|IL1B-convertase|caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)|caspase-1|interleukin 1, beta, convertase|interleukin 1-B converting enzyme
Swissprots	P29466 Q9UCN3 Q6PI75 Q6GSS3 Q53EY6 B5MDZ1 Q6DMQ1
Accessions	AAD15243 EAW67057 EAW67058 EAW67059 EAW67060 EAW67061 P29466 AA505065 AA737419 AA761907 AB102878 BAD89407 AK223503 BAD97223 AK290114 BAF82803 AK290122 BAF82811 AK296646 BAG59246 AK301037 BAG62650 AK310059 AK313516 BAG36296 AY660536 AAT72297 BC041689 AAH41689 BC062327 AAH62327 HQ447656 ADQ32141 M87507 AAA66942 U13697 AAC50107 U13698 AAC50108 U13699 AAC50109 U13700 AAC50110 X65019 CAA46153 XM_006718924 XP_006718987 XM_011543017 XP_011541319 XM_011543018 XP_011541320 NM_001223 NP_001214 NM_001257118 NP_001244047 NM_001257119 NP_001244048 NM_033292 NP_150634 NM_033293 NP_150635 NM_033294 NP_150636 NM_033295 NP_150637
Function	Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. {ECO:0000269|PubMed:15498465, ECO:0000269|PubMed:7876192}.
Subcellular Location	Cytoplasm.
Tissue Specificity	Expressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain. {ECO:0000269|PubMed:15498465}.
Top Pathways	Amyotrophic lateral sclerosis (ALS), NOD-like receptor signaling pathway, Cytosolic DNA-sensing pathway, Pertussis, Influenza A

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CASP1-Over-expression-Lysate - LY11837a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

CASP1 overexpression lysate - LY409611 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

CASP1 overexpression lysate - LY409612 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

CASP1 overexpression lysate - LY409613 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

CASP1 overexpression lysate - LY420065 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

CASP1 overexpression lysate - LY429054 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

CASP1 overexpression lysate - LY429865 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

CASP1 293 Cell Lysate - 405028 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

CASP1 293 Cell Lysate - 405029 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

Caspase-1 Overexpression Lysate (Native) - NBL1-08705 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Caspase-1 Overexpression Lysate (Native) - NBL1-08706 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Caspase-1 Overexpression Lysate (Native) - NBP2-05896 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

CASP1 Over-expression Lysate Product - GWB-ABCDAA from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

CASP1 Over-expression Lysate Product - GWB-1F9F90 from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

Caspase-1 Overexpression Lysate (Denatured) - H00000834-T02 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Panoply™ Human CASP1 Knockdown Stable Cell Line - CSC-DC002389 from Creative biogene Category Cell Line Species Human

CASP1 Knockout Cell Line-HEK293T - CSC-RT1950 from Creative biogene Category Cell Line Species Human

CASP1 Knockout Cell Line-HeLa - CSC-RT1998 from Creative biogene Category Cell Line Species Human

CASP1 KO Cell Lysate-HEK293T - CLKO-1806 from Creative biogene Category Cell Lysate

CASP1 KO Cell Lysate-HeLa - CLKO-1858 from Creative biogene Category Cell Lysate

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