CASP1

Gene Symbol	CASP1
Entrez Gene	834
Alt Symbol	ICE, IL1BC, P45
Species	Human
Gene Type	protein-coding
Description	caspase 1, apoptosis-related cysteine peptidase
Other Description	CASP1 nirs variant 1|IL-1 beta-converting enzyme|IL1B-convertase|caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)|caspase-1|interleukin 1, beta, convertase|interleukin 1-B converting enzyme
Swissprots	P29466 Q9UCN3 Q6PI75 Q6GSS3 Q53EY6 B5MDZ1 Q6DMQ1
Accessions	AAD15243 EAW67057 EAW67058 EAW67059 EAW67060 EAW67061 P29466 AA505065 AA737419 AA761907 AB102878 BAD89407 AK223503 BAD97223 AK290114 BAF82803 AK290122 BAF82811 AK296646 BAG59246 AK301037 BAG62650 AK310059 AK313516 BAG36296 AY660536 AAT72297 BC041689 AAH41689 BC062327 AAH62327 HQ447656 ADQ32141 M87507 AAA66942 U13697 AAC50107 U13698 AAC50108 U13699 AAC50109 U13700 AAC50110 X65019 CAA46153 XM_006718924 XP_006718987 XM_011543017 XP_011541319 XM_011543018 XP_011541320 NM_001223 NP_001214 NM_001257118 NP_001244047 NM_001257119 NP_001244048 NM_033292 NP_150634 NM_033293 NP_150635 NM_033294 NP_150636 NM_033295 NP_150637
Function	Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. {ECO:0000269|PubMed:15498465, ECO:0000269|PubMed:7876192}.
Subcellular Location	Cytoplasm.
Tissue Specificity	Expressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain. {ECO:0000269|PubMed:15498465}.
Top Pathways	Amyotrophic lateral sclerosis (ALS), NOD-like receptor signaling pathway, Cytosolic DNA-sensing pathway, Pertussis, Influenza A

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Caspase-1 full length protein - ab39901 from Abcam Category Protein Prices $303.00 Sizes 25 units Source E. coli Species Human

Human Caspase-1 full length protein - ab158029 from Abcam Category Protein Prices $402.00 Sizes 2 µg Source Wheat germ Species Human

Human Caspase-1 peptide - ab7988 from Abcam Category Peptide Species Human

Human Caspase-1 peptide - ab91439 from Abcam Category Peptide Prices $176.00 Sizes 100 µg Species Human

Human Caspase-1 protein fragment - ab158030 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

CASP1 / Caspase 1 Antibody Blocking Peptide - LS-E30120 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

CASP1 / Caspase 1 Antibody Blocking Peptide - LS-E30121 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

CASP1 / Caspase 1 Antibody Blocking Peptide - LS-E21582 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Caspase-1 Protein - H00000834-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Caspase-1 Protein - H00000834-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Caspase-1 Recombinant Protein - P4033 from Novus Biologicals Category Protein Prices $549.00 Sizes 25 Species Human

Caspase-1 Peptide - NBP1-76606PEP from Novus Biologicals Category Peptide Prices $149.00 Sizes 50 µg Species Human

Caspase-1 Blocking Peptide - NBP1-76605PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

Caspase-1 Protein - NBP1-99225 from Novus Biologicals Category Protein Species Human

Recombinant Human Caspase-1 Protein - NBP1-99608 from Novus Biologicals Category Protein Prices $335.00 Sizes 100 tests Source E. coli. Species Human

CASP1-Antibody-Center-Blocking-Peptide - BP6703c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CASP1-Antibody-N-term-Blocking-Peptide - BP6703a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Caspase-1/ICE Inhibitor Z-WEHD-FMK - FMK002 from R&D Systems Category Peptide Prices $215.00 Sizes 1 mg

Recombinant human Caspase-1 (OPCA00604) - OPCA00604 from Aviva Systems Biology Category Protein Prices $220.00 Sizes 50 µg Species Human

Human Caspase 1 protein - orb245256 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Caspase 1 peptide - orb216995 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

CASP1 Blocking Peptide - 33R-5345 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Caspase 1 Blocking Peptide - 33R-10437 from Fitzgerald Category Peptide Prices $295.00 Sizes 50 µg

Caspase 1 Blocking Peptide - 33R-10593 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

Caspase 1 protein - 30R-2404 from Fitzgerald Category Protein Prices $295.00 Sizes 25 units Source E.coli

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