| Gene Symbol |
BIRC3
|
| Entrez Gene |
330
|
| Alt Symbol |
AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49, c-IAP2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
baculoviral IAP repeat containing 3
|
| Other Description |
IAP homolog C|IAP-1|RING finger protein 49|TNFR2-TRAF signaling complex protein|TNFR2-TRAF-signaling complex protein 1|apoptosis inhibitor 2|baculoviral IAP repeat-containing 3|baculoviral IAP repeat-containing protein 3|inhibitor of apoptosis protein 1|mammalian IAP homolog C
|
| Swissprots |
Q9HC27 Q9UP46 Q13489 Q16628
|
| Accessions |
AAG09369 AAU88144 CBX47599 CBX47600 EAW67017 Q13489 AA805622 AA873008 AF070674 AAC83232 AI880555 BC027485 BC037420 AAH37420 BE907592 BG569841 BQ718651 BU428906 BX415415 BX475964 L43346 L49432 AAC41943 U37546 AAC50507 U45878 AAC50371 XM_011542797 XP_011541099 NM_001165 NP_001156 NM_182962 NP_892007
|
| Function |
Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin- protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin- protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex tha
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:15665297}. Nucleus {ECO:0000269|PubMed:15665297}.
|
| Tissue Specificity |
Highly expressed in fetal lung, and kidney. In the adult, expression is mainly seen in lymphoid tissues, including spleen, thymus and peripheral blood lymphocytes.
|
| Top Pathways |
NOD-like receptor signaling pathway, TNF signaling pathway, Toxoplasmosis, Apoptosis, Small cell lung cancer
|