BIRC3
| Gene Symbol | BIRC3 |
|---|---|
| Entrez Gene | 330 |
| Alt Symbol | AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49, c-IAP2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | baculoviral IAP repeat containing 3 |
| Other Description | IAP homolog C|IAP-1|RING finger protein 49|TNFR2-TRAF signaling complex protein|TNFR2-TRAF-signaling complex protein 1|apoptosis inhibitor 2|baculoviral IAP repeat-containing 3|baculoviral IAP repeat-containing protein 3|inhibitor of apoptosis protein 1|mammalian IAP homolog C |
| Swissprots | Q9HC27 Q9UP46 Q13489 Q16628 |
| Accessions | AAG09369 AAU88144 CBX47599 CBX47600 EAW67017 Q13489 AA805622 AA873008 AF070674 AAC83232 AI880555 BC027485 BC037420 AAH37420 BE907592 BG569841 BQ718651 BU428906 BX415415 BX475964 L43346 L49432 AAC41943 U37546 AAC50507 U45878 AAC50371 XM_011542797 XP_011541099 NM_001165 NP_001156 NM_182962 NP_892007 |
| Function | Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin- protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin- protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex tha |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:15665297}. Nucleus {ECO:0000269|PubMed:15665297}. |
| Tissue Specificity | Highly expressed in fetal lung, and kidney. In the adult, expression is mainly seen in lymphoid tissues, including spleen, thymus and peripheral blood lymphocytes. |
| Top Pathways | NOD-like receptor signaling pathway, TNF signaling pathway, Toxoplasmosis, Apoptosis, Small cell lung cancer |
c-IAP2 CRISPR/Cas9 KO Plasmid (h) - sc-400762 from Santa Cruz Biotechnology
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c-IAP2 HDR Plasmid (h) - sc-400762-HDR from Santa Cruz Biotechnology
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c-IAP2 Double Nickase Plasmid (h) - sc-400762-NIC from Santa Cruz Biotechnology
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c-IAP2 Double Nickase Plasmid (h2) - sc-400762-NIC-2 from Santa Cruz Biotechnology
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c-IAP2 CRISPR Activation Plasmid (h) - sc-400762-ACT from Santa Cruz Biotechnology
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c-IAP2 CRISPR Activation Plasmid (h2) - sc-400762-ACT-2 from Santa Cruz Biotechnology
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c-IAP2 Lentiviral Activation Particles (h) - sc-400762-LAC from Santa Cruz Biotechnology
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c-IAP2 Lentiviral Activation Particles (h2) - sc-400762-LAC-2 from Santa Cruz Biotechnology
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c-IAP2 siRNA (h) - sc-29850 from Santa Cruz Biotechnology
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c-IAP2 shRNA Plasmid (h) - sc-29850-SH from Santa Cruz Biotechnology
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c-IAP2 shRNA (h) Lentiviral Particles - sc-29850-V from Santa Cruz Biotechnology
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cIAP-2/HIAP-1 RNAi - H00000330-R01 from Novus Biologicals
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cIAP-2/HIAP-1 RNAi - H00000330-R02 from Novus Biologicals
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MISSION® esiRNA - EHU067851 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1941 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1941 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05456 from Sigma-Aldrich
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BIRC3 siRNA (Human) - CRH0231 from Cohesion Biosciences
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BIRC3 - MBS8208372 from MyBioSource
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shRNA set against Human BIRC3 (NM_001165.4) - SHH246766 from Creative biogene
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Human BIRC3 siRNA - orb260733 from Biorbyt
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BIRC3 shRNA Plasmid (Human) - CHH0231 from Cohesion Biosciences
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BIRC3 miRNA 3'UTR clone - MiUTR3H-04347 from Creative biogene
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BIRC3 miRNA 3'UTR clone - MiUTR3H-04348 from Creative biogene
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