CD63

Gene Symbol	CD63
Entrez Gene	967
Alt Symbol	LAMP-3, ME491, MLA1, OMA81H, TSPAN30
Species	Human
Gene Type	protein-coding
Description	CD63 molecule
Other Description	CD63 antigen|CD63 antigen (melanoma 1 antigen)|granulophysin|lysosomal-associated membrane protein 3|lysosome-associated membrane glycoprotein 3|melanoma-associated antigen ME491|melanoma-associated antigen MLA1|ocular melanoma-associated antigen|tetraspanin-30|tspan-30
Swissprots	F8VZE2 P08962 Q9UCG6 Q5TZP3 Q8N6Z9
Accessions	CAA44519 EAW96827 EAW96828 EAW96829 P08962 AA583189 AF508304 AAM34259 AK311893 BAG34834 AL582859 AV650763 BC002349 AAH02349 BC013017 AAH13017 BE407235 BG478842 BG766593 BQ434569 BT007073 AAP35736 BT020137 AAV38939 BT020138 AAV38940 BU167765 BU190521 BU960599 CB128206 CD250685 CN296813 CN296834 CN484590 CR542096 CAG46893 DB495090 DQ891248 ABM82174 DQ894433 ABM85359 EB386351 KF998086 AHI51903 M58485 M59907 AAA63235 S93788 AAB21617 X07982 CAA30792 NM_001257389 NP_001244318 NM_001257390 NP_001244319 NM_001257391 NP_001244320 NM_001257392 NP_001244321 NM_001257400 NP_001244329 NM_001257401 NP_001244330 NM_001267698 NP_001254627 NM_001780 NP_001771 NM_001040034
Function	Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli. {ECO:0000269|PubMed:16917503, ECO:0000269|PubMed:2
Subcellular Location	Cell membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Endosome, multivesicular body. Melanosome. Note=Also found in Weibel-Palade bodies of endothelial cells. Located in platelet dense granules. Detected in a subset of pre-melanosomes. Detected on intralumenal vesicles (ILVs) within multivesicular bodies.
Tissue Specificity	Detected in platelets (at protein level). Dysplastic nevi, radial growth phase primary melanomas, hematopoietic cells, tissue macrophages. {ECO:0000269|PubMed:19640571}.
Top Pathways	Lysosome, Proteoglycans in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse CD63 ELISA Kit (Sandwich ELISA) - LS-F6927 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 0.156-10 ng/ml

Human CD63 ELISA Kit (Sandwich ELISA) - LS-F7104 from LifeSpan Bioscience Category ELISA Kit Prices $690.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 0.156-10 ng/ml

Human CD63 ELISA Kit (Sandwich ELISA) - LS-F11093 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 31.2 pg/ml Range 0.156-10 ng/ml

CD63 antigen, CD63, Human, ELISA Kit - E9307h from ARP American Research Products Category ELISA Kit Prices $660.00 Sizes 96 t Range 0.156-10 ng/mL

Tetraspanin 30, TSPAN30/CD63, Human, ELISA Kit - E-EL-H2428 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Tetraspanin 30, TSPAN30, Rabbit, ELISA Kit - E-EL-RB0221 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Tetraspanin 30, TSPAN30, Chicken, ELISA Kit - E-EL-Ch0940 from ARP American Research Products Category ELISA Kit Prices $504.00 Sizes 96 t

Tetraspanin 30, TSPAN30, Porcine, ELISA Kit - E-EL-P0623 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Tetraspanin 30, TSPAN30, Guinea Pig, ELISA Kit - E-EL-GP0670 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Tetraspanin 30, TSPAN30, Monkey, ELISA Kit - E-EL-MK2198 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

CD63 molecule, ELISA Kit - MBS702053 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human CD63 is typically less than 0.156 ng/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 0.625 ng/ml -40 ng/ml.

melanoma-associated antigen, MAGE, ELISA Kit - MBS9304430 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

TSPAN30/CD63, ELISA Kit - MBS2510236 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156--10ng/mL

Human TSPAN30/CD63(Tetraspanin 30) ELISA Kit - E-EL-H2428 from Elabscience Category ELISA Kit Sensitivity 0.10 ng/mL Range 0.16—10 ng/mL

Human TSPAN30/CD63 (Tetraspanin 30) CLIA Kit - E-CL-H1429 from Elabscience Category CLIA Kit Sensitivity 18.75 pg/mL Range Average Recovery (%)

ELISA Kit for Tetraspanin 30 (TSPAN30) - SEB345Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.062ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

CLIA Kit for Tetraspanin 30 (TSPAN30) - SCB345Hu from Uscn Life Science Inc. Category CLIA Kit Sensitivity The minimum detectable dose of this kit is typically less than 5.01pg/mL. Range 13.72-10000pg/mL The standard curve concentrations used for the CLIA’s were 10000pg/mL, 3333.33pg/mL, 1111.11pg/mL, 370.37pg/mL, 123.46pg/mL, 41.15pg/mL, 13.72pg/mL

ELISA Kit for Tetraspanin 30 (TSPAN30) - SEB345Mu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.065ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human cluster of differentiation 63,CD63 ELISA Kit - CSB-E14107h from Cusabio Category ELISA Kit Sensitivity 0.156 ng/ml Range 0.625 ng/ml-40 ng/ml

ELISA Kit for Tetraspanin 30 (TSPAN30) - SEB345Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.062ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

CLIA Kit for Tetraspanin 30 (TSPAN30) - SCB345Hu from Cloud-clone Category CLIA Kit Sensitivity The minimum detectable dose of this kit is typically less than 5.01pg/mL. Range 13.717-10000pg/mL The standard curve concentrations used for the ELISA's were 10000pg/mL, 3333.33pg/mL, 1111.11pg/mL, 370.37pg/mL, 123.457pg/mL, 41.152pg/mL, 13.717pg/mL

Mouse CD63 ELISA Kit (Custom ELISA) - LS-F20379 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Rabbit CD63 ELISA Kit - LS-F20382 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range To be determined

Bovine CD63 ELISA Kit (Custom ELISA) - LS-F20380 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Rat CD63 ELISA Kit (Sandwich ELISA) - LS-F20381 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.312 Range 0.156-10 ng/ml

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