CD63

Gene Symbol	CD63
Entrez Gene	967
Alt Symbol	LAMP-3, ME491, MLA1, OMA81H, TSPAN30
Species	Human
Gene Type	protein-coding
Description	CD63 molecule
Other Description	CD63 antigen|CD63 antigen (melanoma 1 antigen)|granulophysin|lysosomal-associated membrane protein 3|lysosome-associated membrane glycoprotein 3|melanoma-associated antigen ME491|melanoma-associated antigen MLA1|ocular melanoma-associated antigen|tetraspanin-30|tspan-30
Swissprots	F8VZE2 P08962 Q9UCG6 Q5TZP3 Q8N6Z9
Accessions	CAA44519 EAW96827 EAW96828 EAW96829 P08962 AA583189 AF508304 AAM34259 AK311893 BAG34834 AL582859 AV650763 BC002349 AAH02349 BC013017 AAH13017 BE407235 BG478842 BG766593 BQ434569 BT007073 AAP35736 BT020137 AAV38939 BT020138 AAV38940 BU167765 BU190521 BU960599 CB128206 CD250685 CN296813 CN296834 CN484590 CR542096 CAG46893 DB495090 DQ891248 ABM82174 DQ894433 ABM85359 EB386351 KF998086 AHI51903 M58485 M59907 AAA63235 S93788 AAB21617 X07982 CAA30792 NM_001257389 NP_001244318 NM_001257390 NP_001244319 NM_001257391 NP_001244320 NM_001257392 NP_001244321 NM_001257400 NP_001244329 NM_001257401 NP_001244330 NM_001267698 NP_001254627 NM_001780 NP_001771 NM_001040034
Function	Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli. {ECO:0000269|PubMed:16917503, ECO:0000269|PubMed:2
Subcellular Location	Cell membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Endosome, multivesicular body. Melanosome. Note=Also found in Weibel-Palade bodies of endothelial cells. Located in platelet dense granules. Detected in a subset of pre-melanosomes. Detected on intralumenal vesicles (ILVs) within multivesicular bodies.
Tissue Specificity	Detected in platelets (at protein level). Dysplastic nevi, radial growth phase primary melanomas, hematopoietic cells, tissue macrophages. {ECO:0000269|PubMed:19640571}.
Top Pathways	Lysosome, Proteoglycans in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CD63 peptide - ab93074 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

CD63 Antibody Blocking Peptide - LS-E7816 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CD63 Antibody Blocking Peptide - LS-E22232 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CD63-Antibody-C-term-Blocking-peptide - BP5333b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Mouse CD63 antigen (OPCA00042) - OPCA00042 from Aviva Systems Biology Category Protein Prices $220.00 Sizes 50 µg Species Mouse

Human CD63 His tag protein - orb84411 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Species Human

CD63 protein - orb197597 from Biorbyt Category Protein Prices $255.00, $391.00, $519.00 Sizes 10 μg, 50 μg, 100 μg Source E. coli Species Human

CD63 Blocking Peptide - 33R-10413 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Human Tetraspanin 30 Protein - abx069261 from Abbexa Category Protein Source E.coli Species Human

CD63 - H00000967-G01 from Acris Antibodies Category Protein Prices $440.00 Sizes 2 µg Species Human

Recombinant Human CD63 - 230-00272-10 from RayBiotech Category Protein Prices $110.00 Sizes 10 µg Source Escherichia coli (E.coli) Species Human

Recombinant Human CD63 - 230-00272-50 from RayBiotech Category Protein Prices $224.00 Sizes 50 µg Species Human

Recombinant Human CD63 - 230-00272-100 from RayBiotech Category Protein Prices $336.00 Sizes 100 µg Species Human

CD63 fusion protein - ag19680 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

CD63 fusion protein - ag0709 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

CD63 fusion protein - Ag19690 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human CD63, His tagged - CD63-3890H from Creative Biomart Category Protein Source Human Cells Species Human

Recombinant Tetraspanin 30 (TSPAN30) - RPB345Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Tetraspanin 30 (TSPAN30) - RPB345Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Tetraspanin 30 (TSPAN30) - RPB345Mu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

CD63 (K156) Peptide - BS3474P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Tetraspanin 30 (TSPAN30) - RPB345Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human CD63 Protein - H00000967-G01 from Novus Biologicals Category Protein Prices $415.00 Sizes 2 µg Source Wheat Germ Species Human

CD63 Protein - abx163691 from Abbexa Category Protein Species Human

Recombinant Human CD63 antigen(CD63) - CSB-YP004950HU from Cusabio Category Protein Source Yeast Species Human

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