| Gene Symbol | APOA1BP |
|---|---|
| Entrez Gene | 128240 |
| Alt Symbol | AIBP, YJEFN1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | apolipoprotein A-I binding protein |
| Other Description | AI-BP|NAD(P)H-hydrate epimerase|NAD(P)HX epimerase|apoA-I binding protein|apolipoprotein A-I-binding protein|yjeF N-terminal domain-containing protein 1|yjeF_N1 |
| Swissprots | B4DGY3 Q496C6 Q8NCW5 Q5T3I2 |
| Accessions | EAW52941 EAW52942 EAW52943 Q8NCW5 AJ315849 CAC86580 AK294835 BAG57944 AK298222 BAG60492 AK316083 BAH14454 BC056917 AAH56917 BC100931 AAI00932 BC100932 AAI00933 BC100933 AAI00934 BC100934 AAI00935 BG723681 BQ430064 NM_144772 NP_658985 |
| Function | Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. {ECO:0000255|HAMAP-Rule:MF_03159}. |
| Subcellular Location | Mitochondrion {ECO:0000255|HAMAP- Rule:MF_03159}. Secreted {ECO:0000255|HAMAP-Rule:MF_03159, ECO:0000269|PubMed:11991719}. Note=In sperm, secretion gradually increases during capacitation. {ECO:0000255|HAMAP-Rule:MF_03159}. |
| Tissue Specificity | Ubiquitously expressed, with highest levels in kidney, heart and liver. Present in cerebrospinal fluid and urine but not in serum from healthy patients. Present in serum of sepsis patients (at protein level). {ECO:0000269|PubMed:11991719}. |
AI-BP CRISPR/Cas9 KO Plasmid (h) - sc-405792 from Santa Cruz Biotechnology
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AI-BP HDR Plasmid (h) - sc-405792-HDR from Santa Cruz Biotechnology
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AI-BP Double Nickase Plasmid (h) - sc-405792-NIC from Santa Cruz Biotechnology
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AI-BP Double Nickase Plasmid (h2) - sc-405792-NIC-2 from Santa Cruz Biotechnology
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AI-BP CRISPR Activation Plasmid (h) - sc-405792-ACT from Santa Cruz Biotechnology
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AI-BP CRISPR Activation Plasmid (h2) - sc-405792-ACT-2 from Santa Cruz Biotechnology
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AI-BP Lentiviral Activation Particles (h) - sc-405792-LAC from Santa Cruz Biotechnology
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AI-BP Lentiviral Activation Particles (h2) - sc-405792-LAC-2 from Santa Cruz Biotechnology
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AI-BP siRNA (h) - sc-88158 from Santa Cruz Biotechnology
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AI-BP shRNA Plasmid (h) - sc-88158-SH from Santa Cruz Biotechnology
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AI-BP shRNA (h) Lentiviral Particles - sc-88158-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU033771 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3327 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3327 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01297 from Sigma-Aldrich
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APOA1BP siRNA (Human) - CRJ4948 from Cohesion Biosciences
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APOA1BP - MBS8205405 from MyBioSource
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shRNA set against Human APOA1BP (NM_144772.2) - SHH238330 from Creative biogene
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shRNA set against Human APOA1BP(NM_144772.2) - SHG064927 from Creative biogene
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Human APOA1BP siRNA - orb275449 from Biorbyt
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APOA1BP shRNA Plasmid (Human) - CHJ4948 from Cohesion Biosciences
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APOA1BP miRNA 3'UTR clone - MiUTR1H-00469 from Creative biogene
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