| Gene Symbol | CBR1 |
|---|---|
| Entrez Gene | 873 |
| Alt Symbol | CBR, SDR21C1, hCBR1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | carbonyl reductase 1 |
| Other Description | 15-hydroxyprostaglandin dehydrogenase|NADPH-dependent carbonyl reductase 1|carbonyl reductase (NADPH) 1|carbonyl reductase [NADPH] 1|prostaglandin 9-ketoreductase|prostaglandin-E(2) 9-reductase|short chain dehydrogenase/reductase family 21C member 1|short chain dehydrogenase/reductase family 21C, member 1 |
| Swissprots | Q3LHW8 B2RBZ7 B4DFK7 P16152 |
| Accessions | AAA17881 ABK97430 BAA33498 BAA89424 BAA95508 EAX09752 EAX09753 EAX09754 EAX09755 P16152 AB124848 BAE45940 AK294142 BAG57468 AK308691 AK311219 AK314879 BAG37394 AL548852 BC002511 AAH02511 BC015640 AAH15640 BT019843 AAV38646 CR541708 CAG46509 DQ892353 ABM83279 DQ895559 ABM86485 J04056 AAA52070 N51716 NM_001286789 NP_001273718 NM_001757 NP_001748 |
| Function | NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione. {ECO:0000269|PubMed:15799708, ECO:0000269|PubMed:17912391, ECO:0000269|PubMed:18449627, ECO:0000269|PubMed:18826943}. |
| Subcellular Location | Cytoplasm. |
| Top Pathways | Chemical carcinogenesis, Arachidonic acid metabolism, Metabolism of xenobiotics by cytochrome P450 |