CBR1

Gene Symbol CBR1
Entrez Gene 873
Alt Symbol CBR, SDR21C1, hCBR1
Species Human
Gene Type protein-coding
Description carbonyl reductase 1
Other Description 15-hydroxyprostaglandin dehydrogenase|NADPH-dependent carbonyl reductase 1|carbonyl reductase (NADPH) 1|carbonyl reductase [NADPH] 1|prostaglandin 9-ketoreductase|prostaglandin-E(2) 9-reductase|short chain dehydrogenase/reductase family 21C member 1|short chain dehydrogenase/reductase family 21C, member 1
Swissprots Q3LHW8 B2RBZ7 B4DFK7 P16152
Accessions AAA17881 ABK97430 BAA33498 BAA89424 BAA95508 EAX09752 EAX09753 EAX09754 EAX09755 P16152 AB124848 BAE45940 AK294142 BAG57468 AK308691 AK311219 AK314879 BAG37394 AL548852 BC002511 AAH02511 BC015640 AAH15640 BT019843 AAV38646 CR541708 CAG46509 DQ892353 ABM83279 DQ895559 ABM86485 J04056 AAA52070 N51716 NM_001286789 NP_001273718 NM_001757 NP_001748
Function NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione. {ECO:0000269|PubMed:15799708, ECO:0000269|PubMed:17912391, ECO:0000269|PubMed:18449627, ECO:0000269|PubMed:18826943}.
Subcellular Location Cytoplasm.
Top Pathways Chemical carcinogenesis, Arachidonic acid metabolism, Metabolism of xenobiotics by cytochrome P450

Carbonyl reductase 1 (B-11) - sc-390554 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Carbonyl reductase 1 (B-11): sc-390554. Western blot analysis of Carbonyl reductase 1 expression in non-transfected: sc-117752 (A) and mouse Carbonyl reductase 1 transfected: sc-118997 (B) 293T whole cell lysates.

Carbonyl reductase 1 (I-15) - sc-70215 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Carbonyl reductase 1 (I-15): sc-70215. Western blot analysis of Carbonyl reductase 1 expression in non-transfected: sc-117752 (A) and mouse Carbonyl reductase 1 transfected: sc-118997 (B) 293T whole cell lysates.

Carbonyl reductase 1 (H-43) - sc-292866 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Carbonyl reductase 1 (H-43): sc-292866. Western blot analysis of Carbonyl reductase 1 expression in non-transfected: sc-117752 (A) and mouse Carbonyl reductase 1 transfected: sc-118997 (B) 293T whole cell lysates.

Carbonyl reductase 1 (C-18) - sc-70212 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Carbonyl reductase 1 (C-18): sc-70212. Western blot analysis of Carbonyl reductase 1 expression in HeLa (A) and NIH/3T3 (B) whole cell lysates.

Carbonyl reductase 1 (Z-8) - sc-100518 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
Carbonyl reductase 1 (Z-8): sc-100518. Western blot analysis of Carbonyl reductase 1 expression in HeLa whole cell lysate.

Anti-CBR1 antibody - ab4148 from Abcam

Prices $391.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-CBR1 antibody - ab92576 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab92576, at 1/50 dilution, staining CBR1 in paraffin-embedded human breast carcinoma tissue by Immunohistochemistry (Foramlin/PFA-fixed paraffin-embedded sections). Lefthand image without peptide and righthand image with peptide.

Anti-CBR1 antibody - ab186825 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CBR1 antibody (ab186825) at 1/500 dilutionLane 1 : SW480 cell line extractLane 2 : 22RV1 cell line extractLane 3 : MCF7 cell line extractLane 4 : H460 cell line extractLane 5 : SKOV3 cell line extractLane 6 : Mouse kidney cell line extractLane 7 : Mouse liver cell line extractLane 8 : Mouse lung cell line extractLane 9 : Mouse testis cell line extract

Anti-CBR1 antibody - ab75946 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab75946, at a dilution of 1/10, staining CBR1 in formalin fixed, paraffin embedded human breast carcinoma tissue by Immunohistochemistry. ab75946 was peroxidase conjugated to the secondary antibody, followed by DAB staining.

Anti-CBR1 antibody [2C9B12C4] - ab170324 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2C9B12C4
Lane 1 : Lane 2 : Lane 3 : Lane 1 : K562 cell lysateLane 2 : A431 & MDA-MB-468 cell lysateLane 3 : HeLa cell lysate

Anti-CBR1 antibody [4E12] - ab111347 from Abcam

Prices $378.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone 4E12
ICC/IF image of ab111347 stained HeLa cells. The cells were 100% methanol fixed (5 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab111347, 10µg/ml) overnight at +4°C. The secondary antibody (green) was ab96879, DyLight® 488 goat anti-mouse IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-CBR1 antibody [AT4E12] - ab139392 from Abcam

Prices $378.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone AT4E12
All lanes : Anti-CBR1 antibody [AT4E12] (ab139392) at 1/1000 dilutionLane 1 : HeLa cell lysatesLane 2 : HepG2 cell lysatesLane 3 : 293T cell lysatesLysates/proteins at 30 µg per lane.SecondaryGoat anti-mouse secondary antibody conjugated to HRPdeveloped using the ECL technique

Anti-CBR1 antibody [EPR9660] - ab156590 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR9660
ab156590 showing +ve staining in Mouse brain.

Anti-CBR1 antibody (HRP) - ab124170 from Abcam

Prices $376.00
Sizes 100 µl
Host Goat
Clonality Polyclonal
Anti-CBR1 antibody (HRP) (ab124170) at 1/1000 dilution + Human liver lysates in RIPA buffer at 35 µg

Anti-CBR1 antibody - C-terminal - ab151514 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-CBR1 antibody - C-terminal (ab151514) at 1/1000 dilution + A431 whole cell lysate at 30 µg

Anti-CBR / CBR1 Antibody (clone AT4E12) IHC-plus™ - LS-B6268 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone AT4E12
Anti-CBR1 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6268 concentration 10 ug/ml.

Anti-CBR / CBR1 Antibody (aa265-277) - LS-C54615 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Antibody staining (0.2 ug/ml) of Human Liver lysate (RIPA buffer, 30 ug total protein per lane). Primary incubated for 1 hour. Detected by Western blot of chemiluminescence.

Anti-CBR / CBR1 Antibody - LS-C309733 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-CBR / CBR1 Antibody - LS-C307756 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-CBR / CBR1 Antibody - LS-C309735 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CBR / CBR1 Antibody - LS-C341132 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CBR / CBR1 Antibody - LS-C342013 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-CBR / CBR1 Antibody (aa107-156) - LS-C116311 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
CBR1 antibody LS-C116311 Western blot of OVCAR-3 cell lysate.

Anti-CBR / CBR1 Antibody (clone 4G11-1C7) - LS-C196827 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4G11-1C7
Detection limit for recombinant GST tagged CBR1 is approximately 1 ng/ml as a capture antibody.

Anti-CBR / CBR1 Antibody - LS-C335571 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using CBR1 antibody.
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