| Gene Symbol |
NRG3
|
| Entrez Gene |
10718
|
| Alt Symbol |
HRG3, pro-NRG3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
neuregulin 3
|
| Other Description |
neuregulin 3 variant 1|neuregulin 3 variant 10|neuregulin 3 variant 11|neuregulin 3 variant 12|neuregulin 3 variant 13|neuregulin 3 variant 14|neuregulin 3 variant 3|neuregulin 3 variant 4|neuregulin 3 variant 5|neuregulin 3 variant 6|neuregulin 3 variant 7|neuregulin 3 variant 8|neuregulin 3 variant 9|neuregulin-3-like polypeptide|pro-neuregulin-3, membrane-bound isoform
|
| Swissprots |
A4D7U1 Q5VYH3 Q0PEH2 P56975
|
| Accessions |
EAW80374 P56975 AA704915 AK098823 AK122886 BAG53780 AK296563 BAG59183 BC136811 AAI36812 BC143665 DB326565 DQ001411 AAY17216 DQ338459 ABC69293 DQ857894 ABG77979 HM068873 ADK90020 HM068874 ADK90021 HM068875 ADK90022 HM068876 ADK90023 HM068877 ADK90024 HM068878 ADK90025 HM068879 ADK90026 HM068880 ADK90027 HM068881 ADK90028 HM068882 ADK90029 HM068883 ADK90030 HM068884 ADK90031 HM068885 ADK90032 XM_005269444 XP_005269501 XM_011539172 XP_011537474 XM_011539173 XP_011537475 XM_011539174 XP_011537476 XM_011539175 XP_011537477 XM_011539176 XP_011537478 XM_011539177 XP_011537479 XM_011539178 XP_011537480 XM_011539179 XP_011537481 NM_001010848 NP_001010848 NM_001165972 NP_001159444 NM_001165973 NP_001159445
|
| Function |
Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes. {ECO:0000269|PubMed:16478787, ECO:0000269|PubMed:9275162}.
|
| Subcellular Location |
Isoform 3: Cell membrane; Single-pass type I membrane protein. Note=Isoform 3 is also proteolytically released as a soluble form.
|
| Tissue Specificity |
Highly expressed in most regions of the brain with the exception of corpus callosum. Expressed at lower level in testis. Not detected in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, colon and peripheral blood leukocytes.
|
| Top Pathways |
ErbB signaling pathway
|