NRG3

Gene Symbol NRG3
Entrez Gene 10718
Alt Symbol HRG3, pro-NRG3
Species Human
Gene Type protein-coding
Description neuregulin 3
Other Description neuregulin 3 variant 1|neuregulin 3 variant 10|neuregulin 3 variant 11|neuregulin 3 variant 12|neuregulin 3 variant 13|neuregulin 3 variant 14|neuregulin 3 variant 3|neuregulin 3 variant 4|neuregulin 3 variant 5|neuregulin 3 variant 6|neuregulin 3 variant 7|neuregulin 3 variant 8|neuregulin 3 variant 9|neuregulin-3-like polypeptide|pro-neuregulin-3, membrane-bound isoform
Swissprots A4D7U1 Q5VYH3 Q0PEH2 P56975
Accessions EAW80374 P56975 AA704915 AK098823 AK122886 BAG53780 AK296563 BAG59183 BC136811 AAI36812 BC143665 DB326565 DQ001411 AAY17216 DQ338459 ABC69293 DQ857894 ABG77979 HM068873 ADK90020 HM068874 ADK90021 HM068875 ADK90022 HM068876 ADK90023 HM068877 ADK90024 HM068878 ADK90025 HM068879 ADK90026 HM068880 ADK90027 HM068881 ADK90028 HM068882 ADK90029 HM068883 ADK90030 HM068884 ADK90031 HM068885 ADK90032 XM_005269444 XP_005269501 XM_011539172 XP_011537474 XM_011539173 XP_011537475 XM_011539174 XP_011537476 XM_011539175 XP_011537477 XM_011539176 XP_011537478 XM_011539177 XP_011537479 XM_011539178 XP_011537480 XM_011539179 XP_011537481 NM_001010848 NP_001010848 NM_001165972 NP_001159444 NM_001165973 NP_001159445
Function Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes. {ECO:0000269|PubMed:16478787, ECO:0000269|PubMed:9275162}.
Subcellular Location Isoform 3: Cell membrane; Single-pass type I membrane protein. Note=Isoform 3 is also proteolytically released as a soluble form.
Tissue Specificity Highly expressed in most regions of the brain with the exception of corpus callosum. Expressed at lower level in testis. Not detected in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, colon and peripheral blood leukocytes.
Top Pathways ErbB signaling pathway

Neuregulin-3 (D-3) - sc-390171 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Neuregulin-3 (D-3): sc-390171. Western blot analysis of Neuregulin-3 expression in non-transfected (A) and human Neuregulin-3 transfected (B) CMV whole cell lysates.

Neuregulin-3 (D-19) - sc-34223 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Neuregulin-3 (H-70) - sc-67002 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Neuregulin-3 (H-70): sc-67002. Western blot analysis of human recombinant Neuregulin-3.

Neuregulin-3 (P-18) - sc-34225 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Neuregulin-3 (T-19) - sc-34227 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Neuregulin-3 (T-19): sc-34227. Western blot analysis of Neuregulin-3 expression in Jurkat whole cell lysate.

Anti-NRG3 antibody - ab77597 from Abcam

Prices $370.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-NRG3 antibody (ab77597) at 0.3 µg/ml + human brain (cerebellum) lysate in RIPA buffer at 35 µg

Anti-NRG3 antibody - ab83704 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-NRG3 antibody (ab83704) at 1 µg/ml (diluted in 5% skim milk / PBS buffer) + Jurkat Cell Lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-NRG3 antibody [EPR4148] - ab109256 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4148
All lanes : Anti-NRG3 antibody [EPR4148] (ab109256) at 1/1000 dilutionLane 1 : Fetal brain lysateLane 2 : SH-SY5Y lysateLane 3 : C6 lysateLane 4 : Mouse brain lysateLane 5 : Rat brain lysateLysates/proteins at 10 µg per lane.

Anti-NRG3 Antibody (Internal, FITC) - LS-C246661 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NRG3 Antibody (Internal, APC) - LS-C246659 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NRG3 Antibody (Internal, AP) - LS-C246658 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NRG3 Antibody (Internal, Biotin) - LS-C246662 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NRG3 Antibody (Internal, PE) - LS-C246663 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NRG3 Antibody (Internal, Azide-free, HRP) - LS-C248951 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NRG3 Antibody (Internal) - LS-C323454 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NRG3 Antibody (aa709-720) - LS-C61770 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Antibody (0.3 ug/ml) staining of Human Brain (Cerebellum) lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-NRG3 Antibody (Cytoplasmic Domain, clone EPR4148) - LS-C138181 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4148
Western blot analysis on (A) fetal brain, (B) SH-SY5Y, (C) C6, (D) mouse brain, and (E) rat brain lysates using anti-FBNRG3 antibody.

Anti-NRG3 Antibody IHC-plus™ - LS-B107 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-NRG3 antibody IHC of human adrenal medulla. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B107 concentration 20 ug/ml.

Anti-NRG3 Antibody (aa540-589) IHC-plus™ - LS-B5783 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-NRG3 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5783 concentration 5 ug/ml.

Neuregulin-3/NRG3 Antibody - AF753 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Goat
Clonality Polyclonal
Neuregulin‑3/NRG3 was detected in perfusion fixed frozen sections of mouse brain (hippocampus) using Goat Anti-Mouse Neuregulin‑3/NRG3 EGF-like Domain Antigen Affinity-purified Polyclonal Antibody (Catalog # AF753) at 5 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). Specific staining was localized to cell bodies and neuronal processes. View our protocol for Chromogenic IHC Staining of Frozen Tissue Sections.

Neuregulin-3/NRG3 Antibody - NBP1-59338 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Neuregulin 3 Antibody [NBP1-59338] - Jurkat cell lysate, Antibody Titration: 0.2-1 ug/ml.

Neuregulin-3/NRG3 Antibody (EPR4148) - NBP1-95531 from Novus Biologicals

Host Rabbit
Clonality Monoclonal
Clone EPR4148
Western Blot: Neuregulin 3 Antibody (EPR4148) [NBP1-95531] (A) fetal brain, (B) SH-SY5Y, © C6, (D) mouse brain, and (E) rat brain lysates.

Neuregulin-3/NRG3 Antibody - NB100-61670 from Novus Biologicals

Prices $329.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Western Blot: Neuregulin 3 Antibody [NB100-61670] - Analysis of Neuregulin 3 in Human Brain (Cerebellum) lysate (35ug protein in RIPA buffer) using this antibody at 0.3 ug/ml. Primary incubation was 1 hour. Detected by chemiluminescence.

Neuregulin-3/NRG3 Antibody - NBP1-02545 from Novus Biologicals

Prices $329.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Neuregulin-3/NRG3 Antibody [Biotin] - BAF753 from Novus Biologicals

Prices $390.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
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