| Gene Symbol |
DNAJC24
|
| Entrez Gene |
120526
|
| Alt Symbol |
DPH4, JJJ3, ZCSL3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
DnaJ (Hsp40) homolog, subfamily C, member 24
|
| Other Description |
1700030A21Rik|CSL-type zinc finger-containing protein 3|DPH4 homolog (JJJ3, S. cerevisiae)|DPH4, JJJ3 homolog|diphthamide biosynthesis protein 4|dnaJ homolog subfamily C member 24|zinc finger, CSL domain containing 3|zinc finger, CSL-type containing 3
|
| Swissprots |
A8K0V0 I6L9B4 B1ALC1 Q6P3W2
|
| Accessions |
EAW68241 EAW68242 EAW68243 EAW68244 EAW68245 EAW68246 EAW68247 Q6P3W2 AK123087 AK289665 BAF82354 AL050199 AL833128 BC036571 AAH36571 BC044931 BC063804 AAH63804 CD685768 XR_930844 NM_181706 NP_859057
|
| Function |
Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron-binding. The iron- bound form is redox-active and can function as electron carrier. Plays a role in the diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta). {ECO:0000269|PubMed:22367199, ECO:0000269|PubMed:22509046}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton {ECO:0000250}.
|
![Western Blot: DPH4 Overexpression Lysate (Adult Normal) [NBL1-09952] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for DPH4.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/19363_DPH4%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-09952-img0002.jpg)