XRN1

Gene Symbol	XRN1
Entrez Gene	54464
Alt Symbol	SEP1
Species	Human
Gene Type	protein-coding
Description	5'-3' exoribonuclease 1
Other Description	strand-exchange protein 1 homolog
Swissprots	Q8N8U4 Q86WS7 Q4G0S3 Q9UF39 Q6AI24 Q8IZH2 Q6MZS8 Q68D88
Accessions	CBM42916 CBV35649 EAW78971 EAW78972 EAW78973 Q8IZH2 AK096177 BAC04718 AK123897 BAG53979 AK304312 BAG65165 AL117516 AL133623 CAB63749 AY137776 AAN11306 BC039314 AAH39314 BC048104 AAH48104 BC078146 BC141555 AAI41556 BG197321 BX640905 CAE45950 CR627160 CR627396 CAH10490 CR749518 CAH18332 XM_006713673 XP_006713736 XM_011512919 XP_011511221 XM_011512920 XP_011511222 XM_011512921 XP_011511223 XM_011512922 XP_011511224 XM_011512923 XP_011511225 NM_001282857 NP_001269786 NM_001282859 NP_001269788 NM_019001 NP_061874 NM_001042604
Function	Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS). {ECO:0000250, ECO:0000269|PubMed:18172165}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:12515382, ECO:0000269|PubMed:14580940, ECO:0000269|PubMed:9802570}. Note=Discrete foci at the inner surface of the cell membrane.
Tissue Specificity	Expressed in heart, brain, pancreas, spleen, testis, osteogenic sarcoma (OGS) biopsy and primary cell lines. {ECO:0000269|PubMed:12426100}.
Top Pathways	RNA degradation, Ribosome biogenesis in eukaryotes

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Xrn1 full length protein - ab162750 from Abcam Category Protein Source Wheat germ Species Human

XRN1 Antibody Blocking Peptide - LS-E15011 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Xrn1 Recombinant Protein - H00054464-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

XRN1 Blocking Peptide - 33R-5282 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

XRN1 / SEP1 - H00054464-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

XRN1 / SEP1 - H00054464-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

XRN1 fusion protein - Ag19398 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

XRN1 fusion protein - ag18271 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human XRN1, GST-tagged - XRN1-101H from Creative Biomart Category Protein Source Wheat germ Species Human

Recombinant Human XRN1, His-tagged - XRN1-102H from Creative Biomart Category Protein Source E.Coli Species Human

Recombinant Human 5'-3' exoribonuclease 1(XRN1) ,partial - CSB-YP812907HU CSB-EP812907HU CSB-BP812907HU CSB-MP812907HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

5'-3' exoribonuclease 1 (XRN1), partial, Recombinant Protein - MBS1430688 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Xrn1 Protein - NBP1-89420PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

Xrn1 Recombinant Protein Antigen - NBP1-89419PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

XRN1-Blocking-Peptide-C-term - BP21479b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

XRN1 Peptide, Human - M34GP17600H from Creative Peptides Category Peptide Source Synthetic. Species Human

XRN1 Recombinant Protein (OPCD00144) - OPCD00144 from Aviva Systems Biology Category Protein Source E.coli Species Human

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