XRN1

Gene Symbol XRN1
Entrez Gene 54464
Alt Symbol SEP1
Species Human
Gene Type protein-coding
Description 5'-3' exoribonuclease 1
Other Description strand-exchange protein 1 homolog
Swissprots Q8N8U4 Q86WS7 Q4G0S3 Q9UF39 Q6AI24 Q8IZH2 Q6MZS8 Q68D88
Accessions CBM42916 CBV35649 EAW78971 EAW78972 EAW78973 Q8IZH2 AK096177 BAC04718 AK123897 BAG53979 AK304312 BAG65165 AL117516 AL133623 CAB63749 AY137776 AAN11306 BC039314 AAH39314 BC048104 AAH48104 BC078146 BC141555 AAI41556 BG197321 BX640905 CAE45950 CR627160 CR627396 CAH10490 CR749518 CAH18332 XM_006713673 XP_006713736 XM_011512919 XP_011511221 XM_011512920 XP_011511222 XM_011512921 XP_011511223 XM_011512922 XP_011511224 XM_011512923 XP_011511225 NM_001282857 NP_001269786 NM_001282859 NP_001269788 NM_019001 NP_061874 NM_001042604
Function Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS). {ECO:0000250, ECO:0000269|PubMed:18172165}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:12515382, ECO:0000269|PubMed:14580940, ECO:0000269|PubMed:9802570}. Note=Discrete foci at the inner surface of the cell membrane.
Tissue Specificity Expressed in heart, brain, pancreas, spleen, testis, osteogenic sarcoma (OGS) biopsy and primary cell lines. {ECO:0000269|PubMed:12426100}.
Top Pathways RNA degradation, Ribosome biogenesis in eukaryotes

XRN1 (K-20) - sc-50209 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
XRN1 (K-20): sc-50209. Immunoperoxidase staining of formalin fixed, paraffin-embedded human lower stomach tissue showing cytoplasmic staining of glandular cells.

XRN1 (G-2) - sc-165984 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
XRN1 (G-2): sc-165984. Western blot analysis of XRN1 expression in HeLa (A), K-562 (B) and BT-20 (C) whole cell lysates.

XRN1 (H-150) - sc-98459 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
XRN1 (H-150): sc-98459. Immunoperoxidase staining of formalin fixed, paraffin-embedded human lower stomach tissue showing cytoplasmic staining of glandular cells.

XRN1 (C-1) - sc-165985 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
XRN1 (C-1): sc-165985. Western blot analysis of XRN1 expression in HeLa (A), K-562 (B) and BT-20 (C) whole cell lysates.

Anti-Xrn1 antibody - ab70259 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Xrn1 antibody (ab70259) at 1/10000 dilutionLane 1 : Whole cell lysate from HeLa cells at 5 µgLane 2 : Whole cell lysate from HeLa cells at 15 µgLane 3 : Whole cell lysate from HeLa cells at 50 µgdeveloped using the ECL technique

Rabbit Polyclonal to Xrn1 - ab172810 from Abcam

Prices $370.00
Sizes 100 µg
Clonality Polyclonal
All lanes : Rabbit Polyclonal to Xrn1 (ab172810) at 1 µg/mlLane 1 : Xrn1 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateSecondaryGoat Anti-Rabbit IgG (H+L), Peroxidase Conjugated secondary antibody at 1/7500 dilution

Anti-XRN1 Antibody (C-Terminus) - LS-C90796 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-XRN1 Antibody (aa1260-1309) - LS-C110584 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
XRN1 antibody LS-C110584 Western blot of MCF7 cell lysate.

Anti-XRN1 Antibody (C-Terminus) - LS-C287330 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Mouse XRN1 by Western Blot. Samples: Whole cell lysate (50 ug) from NIH3T3, TCMK-1, 4T1, and CT26.WT cells. Antibodies: Affinity purified rabbit anti-XRN1 antibody used for WB at 0.2 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.

Xrn1 Antibody - NB500-191 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Xrn1 Antibody [NB500-191] - Detection of Human XRN1 on HeLa whole cell lysate using NB500-191. XRN1 that was immunoprecipitated by NB500-191 was also blotted with a different affinity purified antibody to an upstream region of XRN1.

Xrn1 Antibody - NBP1-57281 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Xrn1 Antibody [NBP1-57281] - MCF-7 whole cell lysates, concentration 0.2-1 ug/ml.

Xrn1 Antibody - NBP1-89419 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: Xrn1 Antibody [NBP1-89419] - Staining of human cell line U-2 OS shows positivity in plasma membrane and cytoplasm.

Xrn1 Antibody - NBP1-89420 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: Xrn1 Antibody [NBP1-89420] - Staining of human gallbladder shows strong cytoplasmic positivity in glandular cells.

Xrn1 Antibody - H00054464-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-XRN1 antibody produced in rabbit - HPA035005 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-XRN1: <B>Cat. No. HPA035005</B>: Immunohistochemical staining of human pancreas shows strong cytoplasmic positivity in exocrine cells.

Anti-XRN1 antibody produced in rabbit - SAB1401727 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Polyclonal Anti-XRN1, antibody produced in rabbit, purified immunoglobulin: <B>Cat. No. SAB1401727</B>: Antibody concentration: 0.1 - 5.0 μg/mL. Specific band of ~53.80 kDa using XRN1 transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.

Anti-XRN1 antibody produced in rabbit - HPA035006 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-XRN1: <B>Cat. No. HPA035006</B>: Immunohistochemical staining of human testis shows strong cytoplasmic positivity in cells in seminiferus ducts.

Anti-XRN1 antibody produced in rabbit - SAB2102729 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-XRN1: <B>Cat. No.SAB2102729</B>: XRN1 in MCF7 cell lysate with XRN1 antibody at 1.0 μg/mL.

Anti-XRN1 antibody produced in rabbit - SAB4200028 from Sigma-Aldrich

Prices $61.10, $360.00
Sizes 25 µl, 200 µl
Host Rabbit
Clonality Polyclonal

XRN1 antibody - middle region (ARP40931_P050) - ARP40931_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

XRN1 antibody - 70R-4745 from Fitzgerald

Prices $345.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

XRN1 / SEP1 antibody - 23108-1-AP from Acris Antibodies

Prices $270.00
Sizes 150 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded human heart slide using 23108-1-AP( XRN1 Antibody) at dilution of 1:50

XRN1 antibody - 23108-1-AP from Proteintech Group

Prices $279.00
Sizes con: 50 μg/150μl
Host Rabbit
Clonality Polyclonal
HeLa cells were subjected to SDS PAGE followed by western blot with 23108-1-AP(XRN1 antibody) at dilution of 1:600

XRN1, Polyclonal Antibody - MBS647232 from MyBioSource

Prices $615.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

XRN1 - MBS621215 from MyBioSource

Prices $655.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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