| Gene Symbol |
SLC47A1
|
| Entrez Gene |
55244
|
| Alt Symbol |
MATE1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 47 (multidrug and toxin extrusion), member 1
|
| Other Description |
MATE-1|hMATE-1|multidrug and toxin extrusion 1|multidrug and toxin extrusion protein 1|solute carrier family 47, member 1
|
| Swissprots |
Q86VL4 Q53HF5 Q6PD77 Q9NVA3 Q96FL8
|
| Accessions |
EAW50893 EAW50894 EAW50895 Q96FL8 AK001709 BAA91852 AK222625 BAD96345 AK225360 AK293196 BAG56736 AK298254 BAG60519 AK301854 BAG63296 AK302620 BAG63865 AK304647 BAG65424 AK310270 BC010661 AAH10661 BC050592 AAH50592 BC058882 AAH58882 NM_018242 NP_060712
|
| Function |
Solute transporter for tetraethylammonium (TEA), 1- methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide (NMN), metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, ganciclovir and also the zwitterionic cephalosporin, cephalexin and cephradin. Seems to also play a role in the uptake of oxaliplatin (a new platinum anticancer agent). Able to transport paraquat (PQ or N,N-dimethyl-4-4'-bipiridinium); a widely used herbicid. Responsible for the secretion of cationic drugs across the brush border membranes. {ECO:0000269|PubMed:16330770, ECO:0000269|PubMed:16996621, ECO:0000269|PubMed:17495125, ECO:0000269|PubMed:17509534, ECO:0000269|PubMed:17582384}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:16330770, ECO:0000269|PubMed:16641166}; Multi-pass membrane protein {ECO:0000269|PubMed:16330770, ECO:0000269|PubMed:16641166}. Note=Predominantly localized at the plasma membrane but also found in intracellular organelles.
|
| Tissue Specificity |
Expressed in adrenal gland, and to a lower extent in liver, skeletal muscle and kidney (especially found in luminal membranes of the urinary tubules, bile caniculi and brush border membranes). {ECO:0000269|PubMed:16330770, ECO:0000269|PubMed:17509534}.
|