| Gene Symbol |
KDM4C
|
| Entrez Gene |
23081
|
| Alt Symbol |
GASC1, JHDM3C, JMJD2C, TDRD14C
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
lysine (K)-specific demethylase 4C
|
| Other Description |
JmjC domain-containing histone demethylation protein 3C|gene amplified in squamous cell carcinoma 1 protein|jumonji domain-containing protein 2C|lysine-specific demethylase 4C|tudor domain containing 14C
|
| Swissprots |
Q5VYJ3 F5H347 B4E1Y4 Q5VYJ2 B7ZL46 F5H7P0 O94877 Q2M3M0 Q9H3R0 Q5JUC9
|
| Accessions |
EAW58730 EAW58731 EAW58732 EAW58733 EAW58734 Q9H3R0 AB018323 BAA34500 AB037901 BAB16102 AF085959 AI017056 AI969877 AK098534 AK296401 BAH12342 AK303651 BAG64654 AK304032 BAG64946 AK304095 BAG65001 AK310439 AK314355 BC008296 BC036628 BC042976 BC053678 BC060771 BC104859 AAI04860 BC104861 AAI04862 BC143571 AAI43572 BX111090 BX645680 DA470476 HG501878 HG501880 HG501881 LK938950 XM_006716741 XP_006716804 XM_011517808 XP_011516110 XM_011517809 XP_011516111 XM_011517810 XP_011516112 XM_011517811 XP_011516113 XM_011517812 XP_011516114 XM_011517814 XP_011516116 XM_011517815 XP_011516117 XM_011517816 XP_011516118 XR_929221 XR_929222 XR_929223 NM_001146695 NP_001140167 NM_001146696 NP_001140168 NM_001304339 NP_001291268 NM_001304340 NP_001291269 NM_001304341 NP_001291270 NM_015061 NP_055876 NR_130707 NM_001146694
|
| Function |
Histone demethylase that specifically demethylates 'Lys- 9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. {ECO:0000269|PubMed:16603238}.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00537}.
|
| Tissue Specificity |
Overexpressed in several esophageal squamous cell carcinomas (ESCs). {ECO:0000269|PubMed:10987278}.
|