KDM4C

Gene Symbol KDM4C
Entrez Gene 23081
Alt Symbol GASC1, JHDM3C, JMJD2C, TDRD14C
Species Human
Gene Type protein-coding
Description lysine (K)-specific demethylase 4C
Other Description JmjC domain-containing histone demethylation protein 3C|gene amplified in squamous cell carcinoma 1 protein|jumonji domain-containing protein 2C|lysine-specific demethylase 4C|tudor domain containing 14C
Swissprots Q5VYJ3 F5H347 B4E1Y4 Q5VYJ2 B7ZL46 F5H7P0 O94877 Q2M3M0 Q9H3R0 Q5JUC9
Accessions EAW58730 EAW58731 EAW58732 EAW58733 EAW58734 Q9H3R0 AB018323 BAA34500 AB037901 BAB16102 AF085959 AI017056 AI969877 AK098534 AK296401 BAH12342 AK303651 BAG64654 AK304032 BAG64946 AK304095 BAG65001 AK310439 AK314355 BC008296 BC036628 BC042976 BC053678 BC060771 BC104859 AAI04860 BC104861 AAI04862 BC143571 AAI43572 BX111090 BX645680 DA470476 HG501878 HG501880 HG501881 LK938950 XM_006716741 XP_006716804 XM_011517808 XP_011516110 XM_011517809 XP_011516111 XM_011517810 XP_011516112 XM_011517811 XP_011516113 XM_011517812 XP_011516114 XM_011517814 XP_011516116 XM_011517815 XP_011516117 XM_011517816 XP_011516118 XR_929221 XR_929222 XR_929223 NM_001146695 NP_001140167 NM_001146696 NP_001140168 NM_001304339 NP_001291268 NM_001304340 NP_001291269 NM_001304341 NP_001291270 NM_015061 NP_055876 NR_130707 NM_001146694
Function Histone demethylase that specifically demethylates 'Lys- 9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. {ECO:0000269|PubMed:16603238}.
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00537}.
Tissue Specificity Overexpressed in several esophageal squamous cell carcinomas (ESCs). {ECO:0000269|PubMed:10987278}.

JMJD2C (H-300) - sc-98678 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

JMJD2C (S-15) - sc-104949 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
JMJD2C (S-15): sc-104949. Western blot analysis of JMJD2C expression in non-transfected: sc-117752 (A) and mouse JMJD2C transfected: sc-125505 (B) 293T whole cell lysates.

Anti-KDM4 / RPH1 antibody - C-terminal - ab187124 from Abcam

Host Rabbit
Clonality Polyclonal
Anti-KDM4 / RPH1 antibody - C-terminal (ab187124) at 1/1000 dilution + Mouse brain cell extract

Anti-KDM4C / GASC1 / JMJD2C antibody - ab85454 from Abcam

Prices $378.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-KDM4C / GASC1 / JMJD2C antibody (ab85454) at 1 µg/ml + HepG2 cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-KDM4C / GASC1 / JMJD2C antibody - ab27532 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-KDM4C / GASC1 / JMJD2C antibody (ab27532) at 1 µg/mlLane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell LysateLane 2 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell LysateLane 3 : MCF7 (Human breast adenocarcinoma cell line) Whole Cell LysateLysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutionPerformed under reducing conditions.

Anti-KDM4C / GASC1 / JMJD2C antibody - ab40173 from Abcam

Prices $368.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-KDM4C / GASC1 / JMJD2C antibody [4B1] - ab123906 from Abcam

Prices $384.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4B1
ab123906, at 1/50 dilution, staining KDM4C / GASC1 / JMJD2C in paraffin-embedded Human colon tissue by Immunohistochemistry.

Anti-KDM4C / GASC1 / JMJD2C antibody [5B9] - ab123900 from Abcam

Prices $384.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5B9
Overlay histogram showing HeLa cells stained with ab123900 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab123900, 1/50 dilution) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-mouse IgG (H+L) (ab150113) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG1 [ICIGG1] (ab91353, 1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.

Anti-KDM4C / GASC1 / JMJD2C antibody - C-terminal - ab170430 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-KDM4C / GASC1 / JMJD2C antibody - C-terminal (ab170430) at 1/100 dilution + K562 cell lysate at 35 µg

Anti-KDM4C / JMJD2C Antibody (C-Terminus) IHC-plus™ - LS-B3975 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-JMJD2C antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3975 concentration 5 ug/ml.

Anti-KDM4C / JMJD2C Antibody (aa450-600, DY488) - LS-C143501 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-KDM4C / JMJD2C Antibody (aa450-600, Biotin) - LS-C143499 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-KDM4C / JMJD2C Antibody (aa450-600, DY650) - LS-C143500 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-KDM4C / JMJD2C Antibody (aa450-600) IHC-plus™ - LS-B8445 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-JMJD2C antibody IHC of human skin, epidermis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B8445 dilution 1:100.

Anti-KDM4C / JMJD2C Antibody (clone 4B1) - LS-C114684 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4B1
IHC of paraffin-embedded endometrium tissue using anti-KDM4C mouse monoclonal antibody. (Dilution 1:50).

Anti-KDM4C / JMJD2C Antibody (clone 8A1) - LS-C114685 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 8A1
IHC of paraffin-embedded prostate tissue using anti-KDM4C mouse monoclonal antibody. (Dilution 1:50).

Anti-KDM4C / JMJD2C Antibody (aa475-525) IHC-plus™ - LS-B2856 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-JMJD2C antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2856 concentration 5 ug/ml.

Anti-KDM4C / JMJD2C Antibody (aa450-600, HRP) - LS-C143502 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-KDM4C / JMJD2C Antibody (aa1030-1056, AP) - LS-C260683 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KDM4C / JMJD2C Antibody (aa450-600, DY550) - LS-C143503 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-KDM4C / JMJD2C Antibody (aa1030-1056, APC) - LS-C260684 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KDM4C / JMJD2C Antibody (aa1030-1056, FITC) - LS-C260685 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KDM4C / JMJD2C Antibody (aa1030-1056, PE) - LS-C260686 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KDM4C / JMJD2C Antibody (aa685-871, Biotin) - LS-C300346 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-KDM4C / JMJD2C Antibody (aa1030-1056) - LS-C322329 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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