Gene Symbol | PPP1R3C |
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Entrez Gene | 5507 |
Alt Symbol | PPP1R5 |
Species | Human |
Gene Type | protein-coding |
Description | protein phosphatase 1, regulatory subunit 3C |
Other Description | PP1 subunit R5|PTG|Phosphatase 1, regulatory inhibitor subunit 5|protein phosphatase 1 regulatory subunit 3C|protein phosphatase 1 regulatory subunit 5|protein phosphatase 1, regulatory (inhibitor) subunit 3C|protein targeting to glycogen |
Swissprots | O95686 B2R7X0 Q9UQK1 |
Accessions | AAD33215 EAW50107 Q9UQK1 AF087874 AAM10502 AI766011 AK299392 BAG61377 AK299398 BAG61382 AK313149 BAG35967 AM393091 CAL37969 BC012625 AAH12625 BP202053 BX537399 CAD97641 Y18207 CAA77082 NM_005398 NP_005389 |
Function | Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types. {ECO:0000250|UniProtKB:Q7TMB3, ECO:0000269|PubMed:8985175}. |
Top Pathways | Insulin signaling pathway |
PTG CRISPR/Cas9 KO Plasmid (h) - sc-404419 from Santa Cruz Biotechnology
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PTG HDR Plasmid (h) - sc-404419-HDR from Santa Cruz Biotechnology
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PTG Double Nickase Plasmid (h) - sc-404419-NIC from Santa Cruz Biotechnology
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PTG Double Nickase Plasmid (h2) - sc-404419-NIC-2 from Santa Cruz Biotechnology
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PTG CRISPR Activation Plasmid (h) - sc-404419-ACT from Santa Cruz Biotechnology
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PTG CRISPR Activation Plasmid (h2) - sc-404419-ACT-2 from Santa Cruz Biotechnology
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PTG Lentiviral Activation Particles (h) - sc-404419-LAC from Santa Cruz Biotechnology
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PTG Lentiviral Activation Particles (h2) - sc-404419-LAC-2 from Santa Cruz Biotechnology
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PTG siRNA (h) - sc-44047 from Santa Cruz Biotechnology
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PTG shRNA Plasmid (h) - sc-44047-SH from Santa Cruz Biotechnology
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PTG shRNA (h) Lentiviral Particles - sc-44047-V from Santa Cruz Biotechnology
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PPP1R3C RNAi - H00005507-R01 from Novus Biologicals
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MISSION® esiRNA - EHU034111 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0581 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0582 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0580 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17280 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17280 from Sigma-Aldrich
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PPP1R3C siRNA (Human) - CRH3690 from Cohesion Biosciences
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shRNA set against Human PPP1R3C (NM_005398.5) - SHH381236 from Creative biogene
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PPP1R3C shRNA Plasmid (Human) - CHH3690 from Cohesion Biosciences
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PPP1R3C miRNA 3'UTR clone - MiUTR3H-05531 from Creative biogene
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